Interactor 1: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1
Interactor 2: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24166503, 26549445, 32707033, 19050071, 23878393, 26496610, 28351972, 28059666, 19372752, 19270693, 31696776, 31955515, 35271311, 20562859, 20711182, 19270696, 18843052 |
| Identification Methods | affinity chromatography technology, biochemical, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, tandem affinity purification, pull down |
| Interaction Type | physical association, association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | APG6_N~WD40 |
| Common GO terms | GO:0005776 - autophagosome GO:0005829 - cytosol GO:0006622 - protein targeting to lysosome GO:0010506 - regulation of autophagy GO:0016241 - regulation of macroautophagy and 10 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
