Protein: VPS15
Serine/threonine-protein kinase VPS15 (EC 2.7.11.1) (Golgi-retention defective mutant protein 8) (Vacuolar protein sorting-associated protein 15)

Gene: VPS15
Organism: Saccharomyces cerevisiae S288C
Interactions: 79
UniProt ID: P22219

Gene Ontology (top 5):
GO:0000011 - vacuole inheritance
GO:0000139 - Golgi membrane
GO:0000329 - fungal-type vacuole membrane
GO:0000425 - pexophagy
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

646630

VPS34
Phosphatidylinositol 3-kinase VPS34

7

12

Small-scale

0.968

High

646650

PP2C3
Protein phosphatase 2C homolog 3

2

20

High-throughput

0.717

High

646686

BECN1
Vacuolar protein sorting-associated protein 30

5

4

Small-scale

0.709

High

646661

ATG14
Autophagy-related protein 14

6

0

Small-scale

0.697

High

646691

VPS38
Vacuolar protein sorting-associated protein 38

5

0

Small-scale

0.685

High

646679

ATG1
Serine/threonine-protein kinase ATG1

1

19

Small-scale

0.647

High

470735

GPA1
Guanine nucleotide-binding protein alpha-1 subunit

2

5

Small-scale

0.634

High

376269

YPT1
GTP-binding protein YPT1

1

3

High-throughput

0.618

High

458532

SEC4
Ras-related protein SEC4

1

5

High-throughput

0.618

High

646629

VPS15
Serine/threonine-protein kinase VPS15

1

19

High-throughput

0.618

High

646633

KC11
Casein kinase I homolog 1

1

19

High-throughput

0.618

High

646648

YPT7
Ypt/Rab-type GTPase YPT7

1

5

High-throughput

0.618

High

646653

VPS21
Vacuolar protein sorting-associated protein 21

1

12

High-throughput

0.618

High

646654

YPT52
GTP-binding protein YPT52

1

11

High-throughput

0.618

High

646662

YPT31
GTP-binding protein YPT31/YPT8

1

4

High-throughput

0.618

High

646666

AKR1
Palmitoyltransferase AKR1

1

5

High-throughput

0.618

High

646670

KC13
Casein kinase I homolog 3

1

19

High-throughput

0.618

High

646690

ATG38
PtdIns3K complex I subunit atg38

2

0

Small-scale

0.606

High

509402

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

11

Small-scale

0.579

High

488917

SWI6
Regulatory protein SWI6

1

12

High-throughput

0.553

High

646673

DAK2
Dihydroxyacetone kinase 2

1

0

High-throughput

0.518

High

564703

ATC1
Calcium-transporting ATPase 1

1

4

High-throughput

0.479

High

638969

VPS1
Vacuolar protein sorting-associated protein 1

1

4

High-throughput

0.479

High

646631

BET1
Protein transport protein BET1

1

3

High-throughput

0.479

High

646636

CDC48
Cell division control protein 48

1

9

High-throughput

0.479

High

646637

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

646639

COPG
Coatomer subunit gamma

1

6

High-throughput

0.479

High

646643

ATC5
Phospholipid-transporting ATPase DNF1

1

1

High-throughput

0.479

High

646644

EMP24
Endosomal protein P24B

1

1

High-throughput

0.479

High

646645

PEP12
Syntaxin PEP12

1

5

High-throughput

0.479

High

646646

SSO1
Protein SSO1

1

4

High-throughput

0.479

High

646651

CASP
Protein CASP

1

13

High-throughput

0.479

High

646655

DID4
DOA4-independent degradation protein 4

1

1

High-throughput

0.479

High

646658

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

2

High-throughput

0.479

High

646659

ETR1
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

4

High-throughput

0.479

High

646664

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.479

High

646668

SNF7
Vacuolar-sorting protein SNF7

1

2

High-throughput

0.479

High

646671

VAC8
Vacuolar protein 8

1

8

High-throughput

0.479

High

646672

ATC7
Phospholipid-transporting ATPase NEO1

1

4

High-throughput

0.479

High

646682

TMEDA
Endoplasmic reticulum vesicle protein 25

1

2

High-throughput

0.479

High

646683

DID2
Vacuolar protein-sorting-associated protein 46

1

1

High-throughput

0.479

High

646687

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.479

High

646695

YOP1
Protein YOP1

1

1

High-throughput

0.479

High

646667

RV167
Reduced viability upon starvation protein 167

1

4

High-throughput

0.470

High

582415

SEC23
Protein transport protein SEC23

1

0

High-throughput

0.458

High

646210

SEC22
Protein transport protein SEC22

1

0

High-throughput

0.458

High

646640

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.458

High

646642

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.458

High

646657

TVP38
Golgi apparatus membrane protein TVP38

1

0

High-throughput

0.458

High

646660

SFT2
Protein transport protein SFT2

1

0

High-throughput

0.458

High

646663

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.458

High

646665

SVP26
Protein SVP26

1

0

High-throughput

0.458

High

646674

EMP47
Protein EMP47

1

0

High-throughput

0.458

High

646675

SFT1
Protein transport protein SFT1

1

0

High-throughput

0.458

High

646680

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

646681

PRA1
Prenylated Rab acceptor 1

1

0

High-throughput

0.458

High

646688

VTI1
t-SNARE VTI1

1

0

High-throughput

0.458

High

646685

UBC7
Ubiquitin-conjugating enzyme E2 7

1

2

High-throughput

0.457

High

543843

SSB1
Ribosome-associated molecular chaperone SSB1

1

12

High-throughput

0.445

High

646641

HSP7F
Heat shock protein homolog SSE1

1

17

High-throughput

0.445

High

646649

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

597598

CDC23
Anaphase-promoting complex subunit CDC23

1

1

High-throughput

0.437

High

646652

SEG2
Eisosome protein SEG2

1

1

High-throughput

0.437

High

646676

RSF2
Respiration factor 2

1

1

High-throughput

0.437

High

646677

BUL1
Ubiquitin ligase-binding protein BUL1

1

1

High-throughput

0.437

High

646678

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

9

High-throughput

0.437

High

646684

CTF4
DNA polymerase alpha-binding protein

1

2

High-throughput

0.437

High

646689

APC4
Anaphase-promoting complex subunit 4

1

1

High-throughput

0.437

High

646632

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.249

Low

646634

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.249

Low

646635

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.249

Low

646638

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.249

Low

646647

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

646656

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.249

Low

646669

SS120
Protein SSP120

1

0

High-throughput

0.249

Low

646692

YD073
UPF0592 protein YDL073W

1

0

High-throughput

0.249

Low

646693

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.249

Low

646694

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025