Protein: RPN3
26S proteasome regulatory subunit RPN3

Gene: RPN3
Organism: Saccharomyces cerevisiae S288C
Interactions: 153
UniProt ID: P40016

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008541 - proteasome regulatory particle, lid subcomplex
GO:0030234 - enzyme regulator activity
GO:0042176 - regulation of protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

766863

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

26

11

Small-scale

0.990

High

766888

RPN7
26S proteasome regulatory subunit RPN7

10

14

Small-scale

0.977

High

766898

RPN5
26S proteasome regulatory subunit RPN5

10

10

Small-scale

0.974

High

766899

RPN6
26S proteasome regulatory subunit RPN6

9

13

Small-scale

0.967

High

691473

RPN12
26S proteasome regulatory subunit RPN12

7

2

Small-scale

0.965

High

294127

SEM1
26S proteasome complex subunit SEM1

7

0

Small-scale

0.907

High

766895

RPN8
26S proteasome regulatory subunit RPN8

4

9

Small-scale

0.887

High

693308

RPN2
26S proteasome regulatory subunit RPN2

4

8

Small-scale

0.881

High

766884

RPN9
26S proteasome regulatory subunit RPN9

3

9

High-throughput

0.855

High

753820

RPN1
26S proteasome regulatory subunit RPN1

8

8

Small-scale

0.749

High

756931

RPN10
26S proteasome regulatory subunit RPN10

6

1

Small-scale

0.735

High

703905

PRS7
26S proteasome regulatory subunit 7 homolog

5

13

Small-scale

0.712

High

604800

PSB4
Proteasome subunit beta type-4

5

9

Small-scale

0.706

High

766864

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

3

High-throughput

0.694

High

753398

ECM29
Proteasome component ECM29

4

1

High-throughput

0.691

High

697087

RAD23
UV excision repair protein RAD23

4

10

Small-scale

0.683

High

703801

PRS6B
26S proteasome regulatory subunit 6B homolog

4

11

Small-scale

0.683

High

766871

RPN14
26S proteasome regulatory subunit RPN14

3

2

High-throughput

0.667

High

766869

PSD10
Probable 26S proteasome regulatory subunit p28

5

1

Small-scale

0.654

High

703632

PRS6A
26S proteasome regulatory subunit 6A

3

14

High-throughput

0.640

High

597245

PSA7
Probable proteasome subunit alpha type-7

2

8

High-throughput

0.611

High

751163

PSB1
Proteasome subunit beta type-1

2

11

High-throughput

0.611

High

766857

PSA4
Proteasome subunit alpha type-4

2

8

High-throughput

0.611

High

766858

PRS4
26S proteasome regulatory subunit 4 homolog

2

13

High-throughput

0.601

High

766872

PRS10
26S proteasome subunit RPT4

2

16

High-throughput

0.601

High

766878

PRS8
26S proteasome regulatory subunit 8 homolog

2

14

High-throughput

0.601

High

628100

SIS1
Protein SIS1

3

2

High-throughput

0.587

High

141850

RPN13
26S proteasome regulatory subunit RPN13

2

0

High-throughput

0.585

High

619472

PSA2
Proteasome subunit alpha type-2

2

7

High-throughput

0.584

High

766874

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

2

Small-scale

0.584

High

477298

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

8

Small-scale

0.543

High

694775

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.536

High

366348

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.521

High

766855

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.504

High

520612

YPK1
Serine/threonine-protein kinase YPK1

1

2

High-throughput

0.494

High

761176

RGA1
Rho-type GTPase-activating protein 1

1

1

High-throughput

0.494

High

339659

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.489

High

597325

PSA1
Proteasome subunit alpha type-1

1

7

High-throughput

0.479

High

619361

PSA3
Proteasome subunit alpha type-3

1

8

High-throughput

0.479

High

619973

PSB6
Proteasome subunit beta type-6

1

12

High-throughput

0.479

High

625938

PSB2
Proteasome subunit beta type-2

1

8

High-throughput

0.479

High

632488

PSB3
Proteasome subunit beta type-3

1

8

High-throughput

0.479

High

675419

PSB5
Proteasome subunit beta type-5

1

11

High-throughput

0.479

High

675470

PSB7
Proteasome subunit beta type-7

1

11

High-throughput

0.479

High

689184

PSA5
Proteasome subunit alpha type-5

1

7

High-throughput

0.479

High

766856

PSA6
Proteasome subunit alpha type-6

1

7

High-throughput

0.479

High

713174

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

1

High-throughput

0.470

High

757844

HRB1
Serine/arginine

1

1

High-throughput

0.470

High

758043

VPS45
Vacuolar protein sorting-associated protein 45

1

1

High-throughput

0.470

High

758562

HAL5
Serine/threonine-protein kinase HAL5

1

1

High-throughput

0.470

High

766865

ALY2
Arrestin-related trafficking adapter 3

1

2

High-throughput

0.470

High

766892

RGA2
Rho-type GTPase-activating protein 2

1

2

High-throughput

0.470

High

728251

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

491343

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

494065

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

633253

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

695978

HSP79
Heat shock protein homolog SSE2

1

4

High-throughput

0.445

High

472216

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

543807

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

578539

SEC18
Vesicular-fusion protein SEC18

1

4

High-throughput

0.437

High

645471

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

662327

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

680737

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

730810

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

752482

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

766859

MLP2
Protein MLP2

1

1

High-throughput

0.437

High

766860

PSMD9
Probable 26S proteasome regulatory subunit p27

1

1

Small-scale

0.437

High

766875

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

766882

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

766896

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

766901

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

511448

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.407

High

579427

GBB
Guanine nucleotide-binding protein subunit beta

1

2

High-throughput

0.407

High

705222

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

760616

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.407

High

761232

CAJ1
Protein CAJ1

1

2

High-throughput

0.407

High

766866

HLJ1
Protein HLJ1

1

1

High-throughput

0.407

High

766873

JJJ1
J protein JJJ1

1

1

High-throughput

0.407

High

748942

HSM3
DNA mismatch repair protein HSM3

5

0

Small-scale

0.369

High

748237

FTH1
Iron transporter FTH1

2

0

High-throughput

0.307

High

766880

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

532784

ACOX
Acyl-coenzyme A oxidase

1

0

High-throughput

0.282

High

759492

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.282

High

766861

MND2
Anaphase-promoting complex subunit MND2

1

0

High-throughput

0.282

High

766879

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.282

High

429707

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

748351

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

766876

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.279

Low

334483

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.269

Low

530012

STE12
Protein STE12

1

0

High-throughput

0.269

Low

549407

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.269

Low

567477

KHSE
Homoserine kinase

1

0

High-throughput

0.269

Low

597461

PUR6
Phosphoribosylaminoimidazole carboxylase

1

0

High-throughput

0.269

Low

598575

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

0

High-throughput

0.269

Low

600272

SIR1
Regulatory protein SIR1

1

0

High-throughput

0.269

Low

634881

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.269

Low

687537

DBF4
DDK kinase regulatory subunit DBF4

1

0

High-throughput

0.269

Low

710533

PTH2
Peptidyl-tRNA hydrolase 2

1

0

High-throughput

0.269

Low

711113

YKK0
Probable intramembrane protease YKL100C

1

0

High-throughput

0.269

Low

730451

FOLC
Probable folylpolyglutamate synthase

1

0

High-throughput

0.269

Low

747920

PEX32
Peroxisomal membrane protein PEX32

1

0

High-throughput

0.269

Low

762230

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.269

Low

765943

SDD1
Uncharacterized protein YEL057C

1

0

High-throughput

0.269

Low

766870

CWH41
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.269

Low

766887

BSC2
Bypass of stop codon protein 2

1

0

High-throughput

0.269

Low

766890

VTA1
Vacuolar protein sorting-associated protein VTA1

1

0

High-throughput

0.269

Low

766893

TLG2
t-SNARE affecting a late Golgi compartment protein 2

1

0

High-throughput

0.269

Low

766900

YD199
Putative metabolite transport protein YDL199C

1

0

High-throughput

0.269

Low

766902

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.269

Low

746129

FUI1
Uridine permease

1

0

High-throughput

0.265

Low

594132

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

Small-scale

0.261

Low

141620

YP035
Putative uncharacterized protein YPL035C

1

0

High-throughput

0.249

Low

292773

OPI9
Putative uncharacterized protein OPI9

1

0

High-throughput

0.249

Low

383173

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

405648

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

407081

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

413530

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

425976

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

471080

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

480693

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

523275

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

Small-scale

0.249

Low

524321

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

566177

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.249

Low

606656

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

624689

CG22
G2/mitotic-specific cyclin-2

1

0

Small-scale

0.249

Low

631905

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

634620

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

636225

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

688261

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

700438

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

700920

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

706297

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

716435

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

729937

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

745673

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

761583

DSS1
Exoribonuclease II, mitochondrial

1

0

Small-scale

0.249

Low

764953

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.249

Low

766862

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

766867

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

766868

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

766877

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

766881

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

766883

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

766885

SIZ1
E3 SUMO-protein ligase SIZ1

1

0

High-throughput

0.249

Low

766886

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

766889

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

766891

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

766894

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.249

Low

766897

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

541720

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

554655

HSP26
Heat shock protein 26

1

0

High-throughput

0.232

Low

561240

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low

762091

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024