HitPredict

Interactor 1: SET1 (Q5LJZ2)
Histone-lysine N-methyltransferase SETD1 (EC 2.1.1.354)
Gene: SET1

Interactor 2: WDS (Q9V3J8)
Protein will die slowly
Gene: WDS

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22048023, 21694722
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	N-SET~WD40
Common GO terms	GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1641 Dm			1 361
+	Hs
		1080207 EZH2_HUMAN (1099-1624): 1.96e-94: 325: 15.59		FBXW7_HUMAN (4-309): 1.54e-80: 261: 25.16
+	Hs
		975303 KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03		FBXW7_HUMAN (4-309): 1.54e-80: 261: 25.16
+	Hs
		903149 KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03		WDR5_HUMAN (106-361): 3.8e-83: 257: 34.36
+	Hs
		165657 SET1A_HUMAN (1199-1641): 2.01e-74: 277: 40.22		WDR5_HUMAN (106-361): 3.8e-83: 257: 34.36
+	Hs
		1288291 SETD2_HUMAN (1097-1640): 6.27e-83: 305: 13.71		SNR40_HUMAN (106-361): 1.55e-70: 226: 24.06
+	Hs
		903604 KMT2B_HUMAN (1275-1641): 3.52e-69: 260: 28.65		WDR5_HUMAN (106-361): 3.8e-83: 257: 34.36
+	Hs
		975304 KMT2A_HUMAN (1127-1641): 3.09e-76: 284: 22.03		SNR40_HUMAN (106-361): 1.55e-70: 226: 24.06
+	Hs
		152678 KMT2D_HUMAN (1405-1641): 5.95e-61: 234: 37.76		FBXW7_HUMAN (4-309): 1.54e-80: 261: 25.16
+	Hs
		903609 SET1B_HUMAN (27-310): 6.68e-62: 237: 25.90		WDR5_HUMAN (106-361): 3.8e-83: 257: 34.36
+	Hs
		152622 KMT2D_HUMAN (1405-1641): 5.95e-61: 234: 37.76		WDR5_HUMAN (106-361): 3.8e-83: 257: 34.36
+	Hs
		1288387 KMT2B_HUMAN (1275-1641): 3.52e-69: 260: 28.65		SNR40_HUMAN (106-361): 1.55e-70: 226: 24.06
+	Hs
		152663 KMT2D_HUMAN (1405-1641): 5.95e-61: 234: 37.76		WDR5B_HUMAN (106-361): 4.15e-80: 249: 32.05
+	Hs
		331862 NSD2_HUMAN (1382-1640): 5.01e-67: 252: 22.43		SNR40_HUMAN (106-361): 1.55e-70: 226: 24.06
+	At
		1319861 ATX1_ARATH (1365-1641): 7.52e-62: 233: 30.04		WDR5A_ARATH (108-361): 2.43e-76: 239: 31.30
+	Hs
		1288292 NSD3_HUMAN (1398-1640): 6.97e-65: 245: 22.67		SNR40_HUMAN (106-361): 1.55e-70: 226: 24.06
+	Hs
		209441 EZH2_HUMAN (1099-1624): 1.96e-94: 325: 15.59		PLRG1_HUMAN (233-361): 1.71e-26: 111: 24.03
+	Hs
		1317584 SETD2_HUMAN (1097-1640): 6.27e-83: 305: 13.71		NLE1_HUMAN (224-359): 7.45e-32: 126: 21.83
+	Sc
		744551 SET1_YEAST (1086-1641): 2.02e-75: 275: 25.71		SWD3_YEAST (76-357): 1.93e-42: 151: 33.44
+	Zm
		35725 A0A1D6M742_MAIZE (1044-1638): 2.46e-88: 306: 12.78		A0A1D6LQJ4_MAIZE (227-360): 2.63e-25: 105: 24.82
+	Hs
		203735 SUV91_HUMAN (1288-1640): 1.21e-80: 274: 15.80		DAW1_HUMAN (256-361): 2.58e-13: 72.3: 23.73