HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	12607005
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0006281 - DNA repair
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 1233
+	Hs
		799117 BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		854058 KI67_HUMAN (38-1926): 1.25e-69: 263: 9.54		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		1130083 PAXI1_HUMAN (1814-2081): 2.33e-51: 201: 28.11		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		799585 BRCA1_HUMAN (405-2081): 8.49e-75: 279: 8.23		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Hs
		1130076 NIPBL_HUMAN (869-1889): 7.8e-21: 103: 15.38		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		854391 KI67_HUMAN (38-1926): 1.25e-69: 263: 9.54		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Mm
		1235708 NIPBL_MOUSE (1100-1933): 1.13e-16: 89.3: 13.07		SMC1A_MOUSE (1-1233): 6.24e-128: 426: 99.84
+	Hs
		1130128 TITIN_HUMAN (137-816): 5.64e-12: 74.2: 7.90		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		334035 PAXI1_HUMAN (1814-2081): 2.33e-51: 201: 28.11		SMC2_HUMAN (3-1214): 4.82e-78: 283: 18.14
+	Hs
		1257174 PAXI1_HUMAN (1814-2081): 2.33e-51: 201: 28.11		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Hs
		334082 MINT_HUMAN (224-1896): 3.16e-16: 88.1: 11.94		SMC2_HUMAN (3-1214): 4.82e-78: 283: 18.14
+	Hs
		1235693 NIPBL_HUMAN (869-1889): 7.8e-21: 103: 15.38		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Hs
		334065 TITIN_HUMAN (137-816): 5.64e-12: 74.2: 7.90		SMC2_HUMAN (3-1214): 4.82e-78: 283: 18.14
+	Mm
		1235709 NIPBL_MOUSE (1100-1933): 1.13e-16: 89.3: 13.07		SMC3_MOUSE (3-1229): 4.92e-69: 256: 15.78
+	Hs
		1361939 TITIN_HUMAN (137-816): 5.64e-12: 74.2: 7.90		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78