Protein: SMC3
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Mad member-interacting protein 1)

Gene: SMC3
Organism: Mus musculus
Interactions: 28
UniProt ID: Q9CW03

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0000785 - chromatin
GO:0000800 - lateral element
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1362489

SMC1B
Structural maintenance of chromosomes protein 1B

4

17

Small-scale

0.860

High

1423807

SMC1A
Structural maintenance of chromosomes protein 1A

3

18

Small-scale

0.840

High

1223005

RAD21
Double-strand-break repair protein rad21 homolog

2

20

Small-scale

0.737

High

1298089

REC8
Meiotic recombination protein REC8 homolog

2

4

Small-scale

0.737

High

1235709

NIPBL
Nipped-B-like protein

1

18

Small-scale

0.646

High

1283186

NANOG
Homeobox protein NANOG

2

6

Small-scale

0.611

High

1423826

MECP2
Methyl-CpG-binding protein 2

2

6

Small-scale

0.611

High

59830

RD21L
Double-strand-break repair protein rad21-like protein 1

1

20

Small-scale

0.575

High

1223252

ATRX
Transcriptional regulator ATRX

1

17

Small-scale

0.536

High

1362651

EED
Polycomb protein EED

1

6

High-throughput

0.515

High

1341562

CDK8
Cyclin-dependent kinase 8

1

9

Small-scale

0.500

High

98418

E9QPI5
PDS5 cohesin associated factor A

1

20

Small-scale

0.479

High

147872

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.479

High

205301

STAG2
Cohesin subunit SA-2

1

20

Small-scale

0.479

High

267237

STAG3
Cohesin subunit SA-3

1

20

Small-scale

0.479

High

873045

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

947459

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

Small-scale

0.479

High

1047382

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

14

Small-scale

0.479

High

1282492

FACD2
Fanconi anemia group D2 protein homolog

1

8

High-throughput

0.479

High

1283003

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.479

High

1353957

ELF5
ETS-related transcription factor Elf-5

1

6

High-throughput

0.479

High

1423823

NDE1
Nuclear distribution protein nudE homolog 1

1

7

Small-scale

0.479

High

1423817

SYCP2
Synaptonemal complex protein 2

1

0

Small-scale

0.458

High

1423824

HORM1
HORMA domain-containing protein 1

1

0

Small-scale

0.458

High

1230065

CE290
Centrosomal protein of 290 kDa

1

15

Small-scale

0.445

High

1423825

AIRE
Autoimmune regulator

1

13

Small-scale

0.445

High

1297838

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.437

High

1297972

TERB1
Telomere repeats-binding bouquet formation protein 1

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025