HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: K2C78 (Q8N1N4)
Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)
Gene: KRT78

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 520
+	Hs
		110755 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		H6VRG1_HUMAN (76-442): 6.88e-167: 488: 56.95
+	Hs
		1001518 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q0IIN1_HUMAN (66-435): 6.29e-126: 381: 56.49
+	Hs
		729107 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		K22E_HUMAN (83-427): 1.05e-121: 372: 55.65
+	Hs
		409102 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		72923 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		B4DN72_HUMAN (1-499): 1.69e-103: 320: 39.68
+	Hs
		1130283 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		K2C73_HUMAN (4-513): 9.84e-99: 310: 50.19
+	Hs
		380486 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		K2C6B_HUMAN (76-448): 4.72e-80: 262: 59.25
+	Hs
		3119 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A0S2Z428_HUMAN (76-448): 1.02e-78: 258: 59.79
+	Hs
		531584 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		K2C5_HUMAN (76-427): 3.19e-78: 258: 62.50