HitPredict

Interactor 1: CE170 (Q5SW79)
Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)
Gene: CEP170

Interactor 2: TNKS2 (Q9H2K2)
Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)
Gene: TNKS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22153077
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1584 Hs			1 1166
+	Hs
		1056981 MDC1_HUMAN (29-1563): 8.72e-84: 307: 10.03		TNKS2_HUMAN (28-1166): 0: 891: 98.60
+	Hs
		310060 CE170_HUMAN (1-1584): 0: 654: 100.00		TNKS1_HUMAN (2-335): 1.11e-73: 270: 35.95
+	Hs
		310053 MDC1_HUMAN (29-1563): 8.72e-84: 307: 10.03		TNKS1_HUMAN (2-335): 1.11e-73: 270: 35.95
+	Dm
		1182373 Q9VLS7_DROME (601-1577): 6.1e-21: 102: 7.84		Q7KU92_DROME (2-545): 1.17e-116: 402: 25.77
+	Hs
		556716 TITIN_HUMAN (252-1467): 8.36e-24: 112: 8.68		ANK1_HUMAN (1-395): 7.32e-83: 300: 24.09
+	Hs
		166985 TITIN_HUMAN (252-1467): 8.36e-24: 112: 8.68		ANR28_HUMAN (7-525): 2.62e-78: 281: 22.10
+	Hs
		310076 C170L_HUMAN (1275-1584): 2.13e-29: 121: 93.23		TNKS1_HUMAN (2-335): 1.11e-73: 270: 35.95
+	Mm
		57333 A2ARP8_MOUSE (91-1569): 1.96e-49: 196: 9.09		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Mm
		57442 MAP1A_MOUSE (91-1569): 1.8e-49: 196: 9.09		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Hs
		166913 ANK2_HUMAN (318-1298): 5e-14: 80.2: 13.65		ANR28_HUMAN (7-525): 2.62e-78: 281: 22.10
+	Mm
		57341 E9QMK2_MOUSE (661-1584): 5.44e-32: 138: 10.69		A2AM57_MOUSE (489-913): 5.73e-50: 195: 22.49
+	Hs
		807690 MAP1B_HUMAN (175-1557): 2.54e-45: 183: 9.56		ANK2_HUMAN (799-1145): 3.5e-21: 102: 8.73
+	Dm
		1361443 Q9VLS7_DROME (601-1577): 6.1e-21: 102: 7.84		Q9VAU5_DROME (574-1054): 4.29e-45: 180: 13.27
+	Hs
		1021422 MICA3_HUMAN (662-1403): 1.36e-13: 78.7: 12.99		ANK3_HUMAN (836-1140): 9.74e-22: 104: 9.18
+	Dm
		1362722 Q9VLS7_DROME (601-1577): 6.1e-21: 102: 7.84		ANKHM_DROME (827-1055): 9.99e-11: 68.7: 11.39
+	Mm
		103608 ANK2_MOUSE (123-1379): 8.94e-11: 69.4: 13.83		ANK3_MOUSE (836-1140): 1.36e-20: 100: 9.49