HitPredict

Interactor 1: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Interactor 2: MRP2 (Q92887)
ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)
Gene: ABCC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	21059598, 10496535
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 519 Hs			1 1545
+	Hs
		1200079 NHRF4_HUMAN (120-505): 7.2e-35: 139: 23.33		MRP2_HUMAN (1-1545): 0: 1140: 100.00
+	Rn
		1144126 NHRF1_RAT (2-264): 2.21e-38: 145: 29.09		MRP2_RAT (2-1545): 0: 1126: 76.88
+	Hs
		153939 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		MRP2_HUMAN (1-1545): 0: 1140: 100.00
+	Hs
		179363 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		437203 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		MDR1_HUMAN (1018-1540): 1.08e-112: 389: 20.30
+	Hs
		153846 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		179356 SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		179358 NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31
+	Hs
		67899 PDZ1P_HUMAN (6-134): 6.25e-18: 87.9: 28.68		MRP4_HUMAN (888-1542): 1.73e-59: 227: 16.31