HitPredict

Interactor 1: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Interactor 2: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	14531806
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 1235
+	Rn
		92840 DLG4_RAT (3-344): 2.03e-36: 145: 17.22		CTRO_RAT (8-1230): 9.38e-148: 493: 15.98
+	Mm
		823534 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		CTRO_MOUSE (8-1230): 4.45e-138: 465: 16.06
+	Hs
		149188 MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		149084 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Hs
		148800 SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97		CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52
+	Mm
		1143346 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KCC2D_MOUSE (31-423): 9.26e-116: 371: 27.25
+	Mm
		515234 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KCC2A_MOUSE (31-423): 4.29e-113: 364: 25.00
+	Hs
		1271040 DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27		KCC2A_HUMAN (31-423): 1.9e-113: 364: 25.25
+	Rn
		506744 DLG3_RAT (3-359): 6.78e-32: 132: 17.27		KCC2A_RAT (31-423): 4.29e-113: 364: 25.00
+	Mm
		1143553 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KS6A2_MOUSE (2-353): 3.48e-99: 334: 22.13
+	Mm
		250629 LNX1_MOUSE (2-213): 1.09e-19: 94.8: 15.70		KCC2D_MOUSE (31-423): 9.26e-116: 371: 27.25
+	Hs
		1026905 SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97		PAK2_HUMAN (7-305): 1.42e-110: 358: 36.79
+	Hs
		153900 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		KS6A3_HUMAN (22-342): 5.85e-95: 323: 22.49
+	Hs
		1049957 SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97		KS6A2_HUMAN (22-353): 4.19e-97: 328: 22.65
+	Hs
		850651 SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97		KS6A3_HUMAN (22-342): 5.85e-95: 323: 22.49
+	Mm
		949302 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		TNIK_MOUSE (29-323): 2.89e-55: 213: 40.59
+	Mm
		936174 DLG3_MOUSE (3-359): 7.92e-32: 132: 17.27		TNIK_MOUSE (29-323): 2.89e-55: 213: 40.59
+	Hs
		131566 PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84		STK25_HUMAN (28-328): 1.19e-57: 207: 41.31
+	Mm
		949394 DLG2_MOUSE (297-459): 1.94e-19: 94.1: 21.77		TNIK_MOUSE (29-323): 2.89e-55: 213: 40.59
+	Mm
		936586 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		ROCK2_MOUSE (590-1232): 9.09e-16: 85: 10.33