HitPredict

Interactor 1: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Interactor 2: THAP3 (Q8WTV1)
THAP domain-containing protein 3
Gene: THAP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	20200153, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2035 Hs			1 239
+	Hs
		848280 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP7_HUMAN (1-210): 2.2e-49: 165: 23.77
+	Hs
		848301 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP1_HUMAN (1-207): 3.03e-44: 149: 29.47
+	Hs
		848289 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP2_HUMAN (1-136): 8.82e-38: 133: 30.15
+	Hs
		848260 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP6_HUMAN (1-107): 7.79e-34: 123: 29.57
+	Hs
		848270 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THA11_HUMAN (1-158): 3.22e-27: 108: 22.29
+	Hs
		1259626 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		THAP3_HUMAN (1-239): 9.6e-79: 238: 100.00
+	Hs
		1328335 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		THAP2_HUMAN (1-136): 8.82e-38: 133: 30.15
+	Dm
		1359883 HCF_DROME (948-2031): 9.87e-34: 144: 15.87		MBDR2_DROME (1-186): 5.22e-32: 125: 19.56