HitPredict

Interactor 1: KANK4 (Q5T7N3)
KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38)
Gene: KANK4

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 995 Hs			1 2541
+	Hs
		1134818 KANK4_HUMAN (1-995): 0: 590: 99.30		TLN2_HUMAN (1-2541): 0: 1486: 76.10
+	Dm
		65251 A8DYE0_DROME (19-992): 2.51e-92: 322: 18.22		MERH_DROME (83-671): 4.07e-109: 365: 18.32
+	Dm
		1098246 Q7KMM8_DROME (19-992): 4.12e-91: 318: 18.22		MERH_DROME (83-671): 4.07e-109: 365: 18.32
+	Hs
		1330882 Q9H4D1_HUMAN (633-893): 2.26e-16: 86.2: 13.28		MACF1_HUMAN (404-2519): 9.43e-159: 555: 11.11
+	Hs
		1057152 KANK1_HUMAN (3-663): 4.89e-47: 185: 14.71		E41L3_HUMAN (78-1116): 3.01e-115: 397: 11.42
+	Hs
		640252 KANK2_HUMAN (171-982): 1.65e-54: 206: 21.79		PTN3_HUMAN (54-700): 4.26e-96: 336: 16.03
+	Hs
		1206062 MIB1_HUMAN (569-990): 7.28e-53: 202: 14.96		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		166880 ANR28_HUMAN (498-950): 4.75e-57: 216: 13.70		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		299289 Q9H4D1_HUMAN (633-893): 2.26e-16: 86.2: 13.28		FARP2_HUMAN (55-1039): 1.12e-121: 415: 12.54
+	Hs
		547096 KANK2_HUMAN (171-982): 1.65e-54: 206: 21.79		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		1330892 Q9H4D1_HUMAN (633-893): 2.26e-16: 86.2: 13.28		E41L3_HUMAN (78-1116): 3.01e-115: 397: 11.42
+	Hs
		1219853 ANKH1_HUMAN (449-995): 2.33e-35: 148: 13.31		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		1330900 Q9H4D1_HUMAN (633-893): 2.26e-16: 86.2: 13.28		FARP1_HUMAN (52-1026): 1.66e-112: 388: 11.82
+	Dm
		422941 NOTCH_DROME (731-990): 8.47e-34: 143: 18.84		Q9W0R3_DROME (84-965): 6.38e-86: 307: 12.21
+	Hs
		640287 ANR50_HUMAN (546-727): 1.83e-17: 90.2: 12.50		PTN3_HUMAN (54-700): 4.26e-96: 336: 16.03
+	Hs
		257705 ANR17_HUMAN (247-757): 3.55e-12: 73.2: 9.52		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		719616 Q9H4D1_HUMAN (633-893): 2.26e-16: 86.2: 13.28		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		547029 ANK3_HUMAN (342-711): 4.18e-11: 69.8: 7.82		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Rn
		251022 ANK3_RAT (451-804): 5.4e-20: 98.6: 10.06		PLEC_RAT (600-2541): 1.46e-42: 175: 11.13
+	Hs
		1068614 CTTB2_HUMAN (193-885): 2.87e-29: 128: 12.53		PLEC_HUMAN (730-2529): 2.6e-23: 111: 12.52