HitPredict

Interactor 1: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Interactor 2: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	19690564
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Hs			1 353
+	Hs
		1138879 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		Q6GX22_HUMAN (14-337): 5.23e-87: 277: 23.68
+	Hs
		1138880 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		Q6NR77_HUMAN (1-324): 1.03e-80: 251: 99.69
+	Hs
		1138918 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		1138878 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI68_HUMAN (8-353): 5.93e-70: 228: 14.61
+	Hs
		536873 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		1138921 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM2_HUMAN (10-330): 1.64e-63: 216: 19.52
+	Hs
		1138883 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI46_HUMAN (6-344): 4.56e-63: 215: 23.91
+	Hs
		1138920 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM5_HUMAN (10-346): 1.16e-64: 214: 17.49
+	Hs
		135028 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI38_HUMAN (8-352): 1.89e-63: 210: 17.68
+	Hs
		262178 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM3_HUMAN (9-346): 3.33e-61: 210: 17.53
+	Hs
		1138928 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM1_HUMAN (14-345): 3.61e-59: 205: 22.00
+	Hs
		1151762 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		Q6GX22_HUMAN (14-337): 5.23e-87: 277: 23.68
+	Hs
		1317493 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		537142 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		1285831 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI43_HUMAN (10-351): 1.53e-67: 220: 13.74
+	Hs
		175730 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI18_HUMAN (43-337): 4.87e-65: 219: 23.65
+	Hs
		135045 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI38_HUMAN (8-352): 1.89e-63: 210: 17.68
+	Hs
		262201 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM3_HUMAN (9-346): 3.33e-61: 210: 17.53
+	Hs
		1313765 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI62_HUMAN (16-286): 7.47e-58: 196: 22.71
+	Hs
		1204911 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI50_HUMAN (14-250): 3.59e-14: 75.1: 25.00