Protein: SYV
Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS)

Gene: SYV, VAS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 86
UniProt ID: P07806

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004832 - valine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

460349

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

2

High-throughput

0.640

High

460317

HS104
Heat shock protein 104

3

6

High-throughput

0.633

High

460296

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

6

Small-scale

0.618

High

460352

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

2

0

High-throughput

0.595

High

392031

HSP82
ATP-dependent molecular chaperone HSP82

2

9

Small-scale

0.584

High

460304

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.571

High

460311

SIS1
Protein SIS1

2

4

High-throughput

0.571

High

460363

RNH1
Ribonuclease H

2

0

High-throughput

0.563

High

460300

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

460344

SSB2
Ribosome-associated molecular chaperone SSB2

2

7

High-throughput

0.552

High

460365

PIN3
[PSI+] inducibility protein 3

1

1

High-throughput

0.541

High

449043

CALM
Calmodulin

1

1

High-throughput

0.536

High

460326

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.536

High

460348

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.536

High

460357

CDC14
Tyrosine-protein phosphatase CDC14

1

4

High-throughput

0.536

High

460337

KSP1
Serine/threonine-protein kinase KSP1

1

5

High-throughput

0.501

High

460346

PRK1
Actin-regulating kinase PRK1

1

1

Small-scale

0.501

High

460358

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

5

High-throughput

0.501

High

460310

FKBP
FK506-binding protein 1

1

2

High-throughput

0.500

High

460328

VPS21
Vacuolar protein sorting-associated protein 21

1

1

High-throughput

0.500

High

460371

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.500

High

460294

MYO1
Myosin-1

1

2

High-throughput

0.481

High

460306

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.481

High

460307

MYO2
Myosin-2

1

2

Small-scale

0.481

High

460325

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

460335

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

416064

SYTC
Threonine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

416181

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

460293

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.479

High

460298

IPB2
Protease B inhibitor 2

1

1

High-throughput

0.479

High

460303

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

460305

SYKC
Lysine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

460309

PYRC
Dihydroorotase

1

3

High-throughput

0.479

High

460313

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

460315

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

460316

MLS1
Malate synthase 1

1

2

High-throughput

0.479

High

460319

HOG1
Mitogen-activated protein kinase HOG1

1

6

High-throughput

0.479

High

460322

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

460324

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

460329

LONM
Lon protease homolog, mitochondrial

1

7

High-throughput

0.479

High

460331

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

1

High-throughput

0.479

High

460333

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

460338

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

460339

YHI0
Putative proline--tRNA ligase YHR020W

1

10

High-throughput

0.479

High

460340

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

460341

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

460353

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

460356

RAGAB
GTP-binding protein GTR1

1

1

Small-scale

0.479

High

460361

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

460366

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

460370

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.479

High

460312

STE50
Protein STE50

1

0

High-throughput

0.460

High

460332

SEA4
SEH-associated protein 4

1

0

High-throughput

0.460

High

460350

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.460

High

460360

FCP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.460

High

382788

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

460301

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.458

High

460318

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

460334

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

460336

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

460343

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

460345

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

460351

TIM54
Mitochondrial import inner membrane translocase subunit TIM54

1

0

High-throughput

0.458

High

460359

UBC7
Ubiquitin-conjugating enzyme E2 7

1

2

High-throughput

0.457

High

458971

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

High-throughput

0.457

High

460308

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

460323

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

High-throughput

0.457

High

460295

HSP73
Heat shock protein SSA3

1

9

High-throughput

0.445

High

460299

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

460302

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.445

High

460321

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.445

High

460355

JJJ1
J protein JJJ1

1

3

High-throughput

0.445

High

460314

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

460330

PDX3
Pyridoxamine 5'-phosphate oxidase

1

1

High-throughput

0.437

High

460364

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

460367

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

460368

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.437

High

460369

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

460297

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

460327

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.251

Low

460320

IES6
Chromatin-remodeling complex subunit IES6

1

0

High-throughput

0.249

Low

460342

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

460347

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.249

Low

460354

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

Small-scale

0.249

Low

460372

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

460362

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025