Interactor 1: TNAP3 (Q60769)
Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (Putative DNA-binding protein A20) (Zinc finger protein A20)
Gene: Tnfaip3

Interactor 2: RIPK1 (Q60855)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 0.60 0.691

The method score is based on:

Property Details
Experiments 23602765, 21765415, 18246070, 18239685
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0006915 - apoptotic process
GO:0006954 - inflammatory response
GO:0043124 - negative regulation of canonical NF-kappaB signal transduction
GO:0070301 - cellular response to hydrogen peroxide
GO:2001237 - negative regulation of extrinsic apoptotic signaling pathway
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 775
Mm

1 656
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024