HitPredict

Interactor 1: RBBP7 (Q60973)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Interactor 2: Q6AXH7 (Q6AXH7)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356)
Gene: Ezh2

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	23624931
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	EZH2_WD-Binding~WD40, SET~WD40
Common GO terms	GO:0035098 - ESC/E(Z) complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 425 Mm			1 742
+	Mm
		1141935 RBBP4_MOUSE (1-425): 1.17e-114: 343: 89.20		Q6AXH7_MOUSE (1-742): 0: 932: 100.00
+	Mm
		1141957 RBBP7_MOUSE (1-425): 4.03e-119: 355: 100.00		EZH2_MOUSE (1-742): 0: 918: 98.00
+	Hs
		1079986 RBBP7_HUMAN (1-425): 6.93e-119: 354: 99.77		EZH2_HUMAN (1-742): 0: 910: 96.41
+	Mm
		1141929 RBBP4_MOUSE (1-425): 1.17e-114: 343: 89.20		EZH2_MOUSE (1-742): 0: 918: 98.00
+	Hs
		997735 RBBP4_HUMAN (1-425): 1.17e-114: 343: 89.20		EZH2_HUMAN (1-742): 0: 910: 96.41
+	Mm
		936647 RBBP7_MOUSE (1-425): 4.03e-119: 355: 100.00		EZH1_MOUSE (15-741): 0: 812: 63.33
+	Mm
		936646 RBBP4_MOUSE (1-425): 1.17e-114: 343: 89.20		EZH1_MOUSE (15-741): 0: 812: 63.33
+	Hs
		1083337 RBBP7_HUMAN (1-425): 6.93e-119: 354: 99.77		EZH1_HUMAN (15-741): 0: 799: 63.19
+	Hs
		997839 RBBP4_HUMAN (1-425): 1.17e-114: 343: 89.20		EZH1_HUMAN (15-741): 0: 799: 63.19
+	Hs
		975266 RBBP7_HUMAN (1-425): 6.93e-119: 354: 99.77		KMT2A_HUMAN (243-729): 1.42e-70: 254: 18.13
+	At
		187006 MSI4_ARATH (1-423): 1.02e-86: 274: 31.53		CLF_ARATH (259-729): 5.58e-101: 333: 29.18
+	Hs
		203695 RBBP7_HUMAN (1-425): 6.93e-119: 354: 99.77		SUV91_HUMAN (417-727): 3.33e-76: 253: 22.63
+	Mm
		222466 RBBP7_MOUSE (1-425): 4.03e-119: 355: 100.00		SUV91_MOUSE (417-727): 3.98e-75: 250: 22.32
+	Hs
		975233 RBBP4_HUMAN (1-425): 1.17e-114: 343: 89.20		KMT2A_HUMAN (243-729): 1.42e-70: 254: 18.13
+	Hs
		203672 RBBP4_HUMAN (1-425): 1.17e-114: 343: 89.20		SUV91_HUMAN (417-727): 3.33e-76: 253: 22.63
+	Mm
		222465 RBBP4_MOUSE (1-425): 1.17e-114: 343: 89.20		SUV91_MOUSE (417-727): 3.98e-75: 250: 22.32
+	Mm
		1141954 RBBP4_MOUSE (1-425): 1.17e-114: 343: 89.20		EHMT2_MOUSE (430-728): 7.68e-67: 242: 24.45
+	Hs
		997924 RBBP4_HUMAN (1-425): 1.17e-114: 343: 89.20		ASH1L_HUMAN (543-728): 3.01e-56: 211: 30.85
+	Hs
		203735 DAW1_HUMAN (139-422): 2.35e-54: 187: 22.11		SUV91_HUMAN (417-727): 3.33e-76: 253: 22.63
+	Hs
		165666 RBBP4_HUMAN (1-425): 1.17e-114: 343: 89.20		SET1A_HUMAN (607-728): 2.37e-18: 92.4: 38.71