Interactor 1: EZH2 (Q61188)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2)
Gene: EZH2
Interactor 2: EED (Q921E6)
Polycomb protein EED
Gene: EED
Species: Mus musculus
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 1.00 | 0.978 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24457600, 20064375, 20064376, 22438827, 25680957, 22094255, 23624935, 17937919, 20075857, 12900441, 9742080 |
| Identification Methods | affinity chromatography technology, proximity labelling technology, pull down, x-ray crystallography, molecular sieving, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid, coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | EZH2_WD-Binding~WD40, SET~WD40 |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 5 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
