Protein: TMX3
Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)

Gene: TMX3
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q96JJ7

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

699012

CALX
Calnexin

2

20

High-throughput

0.789

High

762154

CNR2
Cannabinoid receptor 2

1

4

Small-scale

0.691

High

1142144

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.691

High

1272621

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

3

High-throughput

0.691

High

697992

CALR
Calreticulin

1

20

High-throughput

0.665

High

951356

SC61B
Protein transport protein Sec61 subunit beta

3

7

High-throughput

0.656

High

820719

CEAM6
Cell adhesion molecule CEACAM6

1

11

High-throughput

0.618

High

1395112

DJC25
DnaJ homolog subfamily C member 25

1

20

High-throughput

0.618

High

904070

BAP31
B-cell receptor-associated protein 31

2

8

High-throughput

0.611

High

1395108

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.578

High

1395118

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.553

High

184213

RER1
Protein RER1

1

1

High-throughput

0.536

High

328721

VAMP5
Vesicle-associated membrane protein 5

1

1

High-throughput

0.536

High

341349

ECEL1
Endothelin-converting enzyme-like 1

1

4

High-throughput

0.536

High

888960

TMEDA
Transmembrane emp24 domain-containing protein 10

1

6

High-throughput

0.536

High

1363123

CLC2B
C-type lectin domain family 2 member B

1

3

High-throughput

0.536

High

1382149

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1395113

EHD4
EH domain-containing protein 4

1

2

High-throughput

0.536

High

1395120

UD17
UDP-glucuronosyltransferase 1A7

1

2

High-throughput

0.536

High

1116562

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.523

High

1286869

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.515

High

593781

PECA1
Platelet endothelial cell adhesion molecule

1

9

High-throughput

0.515

High

1192280

ZACN
Ligand-gated cation channel ZACN

1

0

High-throughput

0.513

High

1395097

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

1

0

High-throughput

0.513

High

1395110

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1395117

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1395131

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.513

High

185936

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

12

High-throughput

0.501

High

422891

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

508448

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

191460

SIA8E
Alpha-2,8-sialyltransferase 8E

1

2

High-throughput

0.489

High

209384

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

2

High-throughput

0.489

High

355372

B3GT4
Beta-1,3-galactosyltransferase 4

1

6

High-throughput

0.489

High

1084061

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

2

High-throughput

0.489

High

1310317

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

1395111

GHC2
Mitochondrial glutamate carrier 2

1

5

High-throughput

0.489

High

174048

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

218631

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

242601

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

412445

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

418360

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

693057

DPP4
Dipeptidyl peptidase 4

1

8

High-throughput

0.479

High

1107666

MTM1
Myotubularin

1

2

High-throughput

0.479

High

1114006

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1249122

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

1322948

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

1333952

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1339137

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1383012

LRC59
Leucine-rich repeat-containing protein 59

1

7

High-throughput

0.479

High

1385226

PLD4
5'-3' exonuclease PLD4

1

8

High-throughput

0.479

High

1395102

SEC62
Translocation protein SEC62

1

4

High-throughput

0.479

High

1395106

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1395115

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

1395116

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1395123

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

1395124

DUS22
Dual specificity protein phosphatase 22

1

4

High-throughput

0.479

High

1395125

T106B
Transmembrane protein 106B

1

6

High-throughput

0.479

High

1395130

VAPA
Vesicle-associated membrane protein-associated protein A

1

7

High-throughput

0.479

High

788148

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.470

High

1351859

NEK7
Serine/threonine-protein kinase Nek7

1

5

High-throughput

0.470

High

48249

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.458

High

133784

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

1031844

LAT1
Large neutral amino acids transporter small subunit 1

1

0

High-throughput

0.458

High

1326728

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.458

High

1395098

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.458

High

1395119

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1395128

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

564220

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.445

High

870286

S6A12
Sodium- and chloride-dependent betaine transporter

1

4

High-throughput

0.445

High

1157191

S15A2
Solute carrier family 15 member 2

1

2

High-throughput

0.445

High

1323750

S39AB
Zinc transporter ZIP11

1

8

High-throughput

0.445

High

106468

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

174584

TRI66
Tripartite motif-containing protein 66

1

15

High-throughput

0.437

High

294182

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

342292

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.437

High

386104

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.437

High

639799

TAF1
Transcription initiation factor TFIID subunit 1

1

10

High-throughput

0.437

High

696225

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768904

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

831251

CCNF
Cyclin-F

1

4

High-throughput

0.437

High

930349

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.437

High

933797

DRG2
Developmentally-regulated GTP-binding protein 2

1

3

High-throughput

0.437

High

1004975

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.437

High

1045646

TF65
Transcription factor p65

1

2

High-throughput

0.437

High

1162494

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.437

High

1163753

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

13

High-throughput

0.437

High

1163860

DUS6
Dual specificity protein phosphatase 6

1

4

High-throughput

0.437

High

1163895

DUS7
Dual specificity protein phosphatase 7

1

8

High-throughput

0.437

High

1238779

TECT3
Tectonic-3

1

13

High-throughput

0.437

High

1252178

SYNE3
Nesprin-3

1

7

High-throughput

0.437

High

1255089

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

1313799

S15A3
Solute carrier family 15 member 3

1

2

High-throughput

0.437

High

1334782

SERB1
SERPINE1 mRNA-binding protein 1

1

6

High-throughput

0.437

High

1392427

TECT2
Tectonic-2

1

13

High-throughput

0.437

High

1395099

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.437

High

1395100

IMP1L
Mitochondrial inner membrane protease subunit 1

1

6

High-throughput

0.437

High

1395101

IMP2L
Mitochondrial inner membrane protease subunit 2

1

6

High-throughput

0.437

High

1395103

RING2
E3 ubiquitin-protein ligase RING2

1

17

High-throughput

0.437

High

1395104

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

9

High-throughput

0.437

High

1395105

DUS9
Dual specificity protein phosphatase 9

1

8

High-throughput

0.437

High

1395109

BRD8
Bromodomain-containing protein 8

1

11

High-throughput

0.437

High

1395122

FBX6
F-box only protein 6

1

2

High-throughput

0.437

High

1395132

TRI33
E3 ubiquitin-protein ligase TRIM33

1

15

High-throughput

0.437

High

1335678

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

104207

F5H1C8
Solute carrier family 15 member 3

1

2

High-throughput

0.407

High

1308937

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

295758

AP1G2
AP-1 complex subunit gamma-like 2

2

0

High-throughput

0.328

High

1273271

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

1395107

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.279

Low

1395114

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.279

Low

1395127

BABA2
BRISC and BRCA1-A complex member 2

1

0

High-throughput

0.279

Low

1252443

M3K15
Mitogen-activated protein kinase kinase kinase 15

1

0

High-throughput

0.249

Low

1395121

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.249

Low

1395126

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1395129

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1253202

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1260505

S35D2
Nucleotide sugar transporter SLC35D2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025