HitPredict

Interactor 1: DLL1 (Q61483)
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) [Cleaved into: Dll1-soluble form (Dll1-EC) (Shed form); Dll1-derived cell-associated form (Dll1-TMIC) (Membrane-associated fragment); Dll1-intracellular form (Dll1-IC)]
Gene: DLL1

Interactor 2: MAGI2 (Q9WVQ1)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Activin receptor-interacting protein 1) (Acvrip1) (Atrophin-1-interacting protein 1) (AIP-1) (Membrane-associated guanylate kinase inverted 2) (MAGI-2)
Gene: MAGI2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.591

Property	Details
Experiments	24025447, 14529612
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation GO:0032991 - protein-containing complex GO:0072583 - clathrin-dependent endocytosis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 722 Mm			1 1275
+	Mm
		1337456 DLL4_MOUSE (2-231): 1.66e-14: 79.2: 12.03		MAGI2_MOUSE (1-1275): 0: 741: 100.00
+	Mm
		1142614 DLL1_MOUSE (1-722): 2.09e-107: 344: 100.00		MAGI3_MOUSE (18-392): 1.16e-21: 104: 11.66
+	Mm
		1142611 DLL1_MOUSE (1-722): 2.09e-107: 344: 100.00		MPDZ_MOUSE (1082-1248): 1.12e-13: 78.6: 19.77
+	Hs
		125785 NOTC3_HUMAN (2-641): 5.71e-46: 179: 19.10		WWP2_HUMAN (179-414): 1.95e-30: 132: 22.63
+	Hs
		804164 NOTC1_HUMAN (2-330): 2.1e-12: 73: 11.71		NEDD4_HUMAN (88-421): 3.25e-60: 229: 19.46
+	Hs
		1049987 DLK2_HUMAN (312-530): 6.3e-38: 147: 40.89		SCRIB_HUMAN (5-786): 7.16e-13: 75.9: 8.25
+	Dm
		422918 NOTCH_DROME (321-717): 1.22e-28: 125: 19.52		NEDD4_DROME (277-380): 2.08e-11: 70.9: 32.14
+	Mm
		82714 B9EJ72_MOUSE (442-720): 4.43e-23: 107: 8.73		DLG4_MOUSE (370-517): 3.1e-16: 86.3: 15.54
+	Mm
		1322297 DLL4_MOUSE (2-231): 1.66e-14: 79.2: 12.03		MAGI3_MOUSE (18-392): 1.16e-21: 104: 11.66
+	Ce
		86397 GLP1_CAEEL (162-377): 2.48e-14: 79: 22.13		C1P633_CAEEL (5-243): 2.59e-19: 96.7: 16.74
+	Mm
		1257409 DLL4_MOUSE (2-231): 1.66e-14: 79.2: 12.03		MPDZ_MOUSE (1082-1248): 1.12e-13: 78.6: 19.77
+	Hs
		946788 CRUM1_HUMAN (26-289): 4.79e-12: 71.8: 16.03		INADL_HUMAN (14-135): 3.36e-14: 80.2: 17.60
+	Hs
		804291 NOTC1_HUMAN (2-330): 2.1e-12: 73: 11.71		LNX2_HUMAN (1132-1256): 5.19e-14: 78.8: 24.41
+	Ce
		88191 GLP1_CAEEL (162-377): 2.48e-14: 79: 22.13		D3YT29_CAEEL (18-103): 5.78e-11: 69.2: 21.84
+	Dm
		484997 CRB_DROME (2-288): 9e-10: 64.6: 13.40		PATJ_DROME (1087-1275): 2.29e-15: 83.5: 18.85
+	Hs
		804323 NOTC1_HUMAN (2-330): 2.1e-12: 73: 11.71		NED4L_HUMAN (267-381): 1.02e-10: 68.6: 36.07
+	Dm
		485004 CRB_DROME (2-288): 9e-10: 64.6: 13.40		Q9VX75_DROME (17-198): 3.11e-10: 67.3: 17.20
+	Dm
		484987 CRB_DROME (2-288): 9e-10: 64.6: 13.40		Q0KHR3_DROME (17-198): 6.11e-10: 66.1: 17.20
+	Hs
		980471 NOTC2_HUMAN (2-290): 4.72e-10: 65.3: 10.89		PARD3_HUMAN (431-785): 7.22e-09: 62.6: 14.61