Protein: BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4)

Gene: BCKD, BCKDK
Organism: Homo sapiens
Interactions: 144
UniProt ID: O14874

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

166628

CETN2
Centrin-2

4

2

High-throughput

0.699

High

166608

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.691

High

166609

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.691

High

166587

CETN3
Centrin-3

4

2

High-throughput

0.638

High

166635

RM12
Large ribosomal subunit protein bL12m

2

2

High-throughput

0.628

High

166684

WDTC1
WD and tetratricopeptide repeats protein 1

3

3

High-throughput

0.609

High

166678

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

166589

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

166647

LG3BP
Galectin-3-binding protein

2

1

High-throughput

0.574

High

166648

CETN1
Centrin-1

2

2

High-throughput

0.574

High

166620

DNJB1
DnaJ homolog subfamily B member 1

2

1

High-throughput

0.558

High

166588

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

3

High-throughput

0.536

High

166592

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

3

High-throughput

0.536

High

166593

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

3

High-throughput

0.536

High

166613

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.536

High

166621

KAD4
Adenylate kinase 4, mitochondrial

1

4

High-throughput

0.536

High

166625

BASI
Basigin

1

2

High-throughput

0.536

High

166631

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

4

High-throughput

0.536

High

166637

KAD2
Adenylate kinase 2, mitochondrial

1

4

High-throughput

0.536

High

166654

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.536

High

166656

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

1

High-throughput

0.536

High

166662

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.536

High

166677

ADCK1
AarF domain-containing protein kinase 1

1

1

High-throughput

0.536

High

166683

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

2

High-throughput

0.536

High

166694

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

166695

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

2

High-throughput

0.536

High

166696

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

1

High-throughput

0.536

High

166699

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.536

High

166709

NPS3A
Protein NipSnap homolog 3A

1

3

High-throughput

0.536

High

166717

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

166721

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

3

High-throughput

0.536

High

166722

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

3

High-throughput

0.536

High

166655

CUL3
Cullin-3

2

2

High-throughput

0.533

High

166627

STAT3
Signal transducer and activator of transcription 3

1

2

High-throughput

0.523

High

166602

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

166616

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

10

High-throughput

0.515

High

137558

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.513

High

166594

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

166599

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.513

High

166607

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.513

High

166626

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.513

High

166636

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.513

High

166661

TAZ
Tafazzin

1

0

High-throughput

0.513

High

166672

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

166673

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

166676

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.513

High

166681

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.513

High

166698

TRABD
TraB domain-containing protein

1

0

High-throughput

0.513

High

166707

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

166711

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

166712

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

166632

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.494

High

166633

FXR2
RNA-binding protein FXR2

1

1

High-throughput

0.494

High

135754

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.493

High

124687

AIP
AH receptor-interacting protein

1

6

High-throughput

0.489

High

166604

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

3

High-throughput

0.489

High

166611

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

3

High-throughput

0.489

High

166614

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

1

High-throughput

0.489

High

166622

MAP4
Microtubule-associated protein 4

1

2

High-throughput

0.489

High

166623

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

High-throughput

0.489

High

166624

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.489

High

166641

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

3

High-throughput

0.489

High

166643

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.489

High

166644

BASP1
Brain acid soluble protein 1

1

1

High-throughput

0.489

High

166645

SHC2
SHC-transforming protein 2

1

2

High-throughput

0.489

High

166649

TP53B
TP53-binding protein 1

1

1

High-throughput

0.489

High

166652

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.489

High

166658

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.489

High

166660

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.489

High

166686

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

1

High-throughput

0.489

High

166690

TRI43
Tripartite motif-containing protein 43

1

1

High-throughput

0.489

High

166693

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.489

High

166706

HCST
Hematopoietic cell signal transducer

1

1

High-throughput

0.489

High

166708

ZO2
Tight junction protein 2

1

1

High-throughput

0.489

High

137517

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

2

High-throughput

0.481

High

166719

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

166603

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

166610

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

10

High-throughput

0.479

High

166618

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.479

High

166630

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

166638

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

166646

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

166682

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

2

High-throughput

0.479

High

166688

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

166703

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

166595

SRBS2
Sorbin and SH3 domain-containing protein 2

1

1

High-throughput

0.470

High

166700

CB39L
Calcium-binding protein 39-like

1

1

High-throughput

0.470

High

166718

CAB39
Calcium-binding protein 39

1

1

High-throughput

0.470

High

166596

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.458

High

166653

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

166605

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

135408

DNM1L
Dynamin-1-like protein

1

1

Small-scale

0.445

High

166666

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

166598

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

2

High-throughput

0.439

High

166634

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.437

High

166640

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

4

High-throughput

0.437

High

166669

TENS2
Tensin-2

1

2

High-throughput

0.437

High

166671

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

166674

TRI72
Tripartite motif-containing protein 72

1

1

Small-scale

0.437

High

166675

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

166697

ZBP1
Z-DNA-binding protein 1

1

1

High-throughput

0.437

High

166713

XPO7
Exportin-7

1

1

High-throughput

0.437

High

166714

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

166720

TLN1
Talin-1

1

1

Small-scale

0.437

High

166600

IGHM
Immunoglobulin heavy constant mu

1

2

High-throughput

0.407

High

166615

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

4

High-throughput

0.407

High

166665

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

4

High-throughput

0.407

High

166670

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.407

High

154776

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

166667

MT21C
Protein-lysine methyltransferase METTL21C

3

0

High-throughput

0.345

High

166597

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

2

0

High-throughput

0.328

High

166601

SPTA1
Spectrin alpha chain, erythrocytic 1

2

0

High-throughput

0.316

High

162297

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.279

Low

166590

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.279

Low

166591

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

166606

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

0

High-throughput

0.279

Low

166619

EGLN
Endoglin

1

0

High-throughput

0.279

Low

166629

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.279

Low

166639

TMM33
Transmembrane protein 33

1

0

High-throughput

0.279

Low

166657

RBM39
RNA-binding protein 39

1

0

High-throughput

0.279

Low

166679

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.279

Low

166680

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

166685

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

166691

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.279

Low

166692

RSLAB
Ras-like protein family member 10B

1

0

High-throughput

0.279

Low

166701

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.279

Low

166702

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

166704

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.279

Low

166705

GBG12

1

0

High-throughput

0.279

Low

166715

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.279

Low

166716

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

166723

SNX9
Sorting nexin-9

1

0

High-throughput

0.279

Low

166663

FA98B
Protein FAM98B

1

0

High-throughput

0.269

Low

166687

BRK1
Protein BRICK1

1

0

High-throughput

0.268

Low

166612

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

166650

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.251

Low

166617

LYL1
Protein lyl-1

1

0

High-throughput

0.249

Low

166651

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.249

Low

166659

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

166668

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

166689

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.249

Low

166710

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

166642

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.232

Low

166664

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025