Protein: PDK3
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)

Gene: PDK3
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q15120

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1142547

PDK1
[Pyruvate dehydrogenase

5

11

High-throughput

0.922

High

1142737

PDK4
[Pyruvate dehydrogenase

4

11

High-throughput

0.900

High

1142723

PDK2
[Pyruvate dehydrogenase

3

11

High-throughput

0.871

High

522429

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

4

9

Small-scale

0.698

High

461494

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.691

High

468390

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.691

High

471036

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

4

10

Small-scale

0.691

High

532596

CH60
60 kDa heat shock protein, mitochondrial

3

4

High-throughput

0.667

High

539181

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

3

6

High-throughput

0.667

High

1142767

ACAD9
Complex I assembly factor ACAD9, mitochondrial

3

6

High-throughput

0.667

High

1142738

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

1

Small-scale

0.640

High

484542

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

1142761

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

3

0

High-throughput

0.638

High

132850

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

2

9

High-throughput

0.628

High

275294

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

3

High-throughput

0.628

High

610671

TCPA
T-complex protein 1 subunit alpha

2

11

High-throughput

0.628

High

715319

ODPAT
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

2

9

High-throughput

0.628

High

821361

TCPZ
T-complex protein 1 subunit zeta

2

11

High-throughput

0.628

High

875971

TCPE
T-complex protein 1 subunit epsilon

2

14

High-throughput

0.628

High

881935

TCPG
T-complex protein 1 subunit gamma

2

14

High-throughput

0.628

High

899048

TCPQ
T-complex protein 1 subunit theta

2

17

High-throughput

0.628

High

899394

TCPD
T-complex protein 1 subunit delta

2

11

High-throughput

0.628

High

1007025

TCPB
T-complex protein 1 subunit beta

2

14

High-throughput

0.628

High

1142756

TCPH
T-complex protein 1 subunit eta

2

14

High-throughput

0.628

High

1090404

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.618

High

1123294

ICT1
Large ribosomal subunit protein mL62

2

1

High-throughput

0.611

High

1142746

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

363308

EGFR
Epidermal growth factor receptor

2

3

Small-scale

0.608

High

1142745

SYT12
Synaptotagmin-12

3

1

High-throughput

0.604

High

1142740

DNLZ
DNL-type zinc finger protein

2

0

High-throughput

0.602

High

241734

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

279765

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

85098

B7Z207
Protein-serine/threonine kinase

1

11

High-throughput

0.575

High

838364

STA5A
Signal transducer and activator of transcription 5A

2

2

High-throughput

0.574

High

1091183

FOXD4
Forkhead box protein D4

2

3

High-throughput

0.574

High

869163

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

4

High-throughput

0.536

High

934641

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

1142757

NPS3B
Protein NipSnap homolog 3B

1

3

High-throughput

0.536

High

1142777

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.536

High

396147

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

910526

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.515

High

598093

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

High-throughput

0.513

High

946489

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

1127718

HLTF
Helicase-like transcription factor

1

0

High-throughput

0.513

High

638422

FPR1
fMet-Leu-Phe receptor

1

5

High-throughput

0.489

High

731315

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.489

High

61506

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

66202

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

281955

MPPB
Mitochondrial-processing peptidase subunit beta

1

4

High-throughput

0.479

High

287294

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

350872

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

519117

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

786100

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

828780

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

841746

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

851895

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856268

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

1048520

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1058031

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1083616

MPPA
Mitochondrial-processing peptidase subunit alpha

1

4

High-throughput

0.479

High

1087394

GRSF1
G-rich sequence factor 1

1

2

High-throughput

0.479

High

1117736

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

1142739

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1142741

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1142743

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

1142744

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

4

High-throughput

0.479

High

1142749

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1142750

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

1142751

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.479

High

1142753

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1142755

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.479

High

1142758

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1142759

TR61B
tRNA

1

2

High-throughput

0.479

High

1142760

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1142762

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1142763

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1142764

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1142766

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1142769

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1142771

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

4

High-throughput

0.479

High

1142773

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1142774

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1046

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.464

High

279371

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

293714

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

315604

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

882683

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

1024047

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1142752

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1142770

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1142772

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1142778

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

422131

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

159660

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.437

High

588748

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

695514

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768246

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1026392

HSF1
Heat shock factor protein 1

1

1

Small-scale

0.437

High

1113150

CUL3
Cullin-3

1

2

High-throughput

0.437

High

1114832

CUL4A
Cullin-4A

1

2

High-throughput

0.437

High

1142742

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1142754

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

1142765

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1142776

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

429922

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

538755

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

4

High-throughput

0.407

High

351106

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.279

Low

570892

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.279

Low

789899

FDFT
Squalene synthase

1

0

High-throughput

0.279

Low

862650

UTRN
Utrophin

1

0

High-throughput

0.279

Low

867786

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.279

Low

1140279

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.279

Low

1142747

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.279

Low

130107

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

377575

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1142748

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1142768

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1142775

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025