HitPredict

Interactor 1: JAK2 (Q62689)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: SH2B1 (Q62985)
SH2B adapter protein 1 (FceRI gamma-chain-interacting protein SH2-B) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)
Gene: SH2B1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17565041
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Rn			1 756
+	Mm
		1143573 JAK2_MOUSE (1-1132): 0: 1165: 98.06		SH2B1_MOUSE (1-756): 0: 550: 98.28
+	Hs
		238440 JAK2_HUMAN (1-1132): 0: 1157: 94.61		SH2B1_HUMAN (1-756): 7.57e-169: 506: 90.63
+	Hs
		145961 JAK2_HUMAN (1-1132): 0: 1157: 94.61		SH2B2_HUMAN (25-755): 1.33e-132: 408: 34.20
+	Mm
		1143584 JAK3_MOUSE (18-1132): 0: 925: 47.00		SH2B1_MOUSE (1-756): 0: 550: 98.28
+	Hs
		238446 JAK2_HUMAN (1-1132): 0: 1157: 94.61		SH2B3_HUMAN (480-754): 3.59e-68: 237: 38.04
+	Mm
		140162 JAK2_MOUSE (1-1132): 0: 1165: 98.06		SH2B3_MOUSE (480-754): 3.2e-61: 217: 37.59
+	Mm
		403446 JAK2_MOUSE (1-1132): 0: 1165: 98.06		SRC_MOUSE (382-701): 5.65e-60: 213: 11.91
+	Mm
		980968 JAK2_MOUSE (1-1132): 0: 1165: 98.06		YES_MOUSE (387-704): 3.99e-59: 211: 13.61
+	Hs
		238332 JAK2_HUMAN (1-1132): 0: 1157: 94.61		LYN_HUMAN (404-701): 6.79e-62: 218: 13.82
+	Hs
		238342 JAK2_HUMAN (1-1132): 0: 1157: 94.61		SRC_HUMAN (391-701): 3.04e-61: 217: 12.54
+	Hs
		238380 JAK2_HUMAN (1-1132): 0: 1157: 94.61		TEC_HUMAN (291-701): 1.79e-57: 208: 13.74
+	Hs
		238330 JAK2_HUMAN (1-1132): 0: 1157: 94.61		FYN_HUMAN (394-701): 1.38e-56: 204: 13.64
+	Mm
		957236 JAK2_MOUSE (1-1132): 0: 1165: 98.06		SHC1_MOUSE (396-616): 4.43e-50: 187: 21.83
+	Hs
		238363 JAK2_HUMAN (1-1132): 0: 1157: 94.61		SHC1_HUMAN (378-616): 1.61e-51: 191: 23.01
+	Hs
		238395 JAK2_HUMAN (1-1132): 0: 1157: 94.61		GRB2_HUMAN (517-609): 4.55e-15: 77: 22.58
+	Hs
		433605 TYK2_HUMAN (38-1132): 0: 876: 35.94		LYN_HUMAN (404-701): 6.79e-62: 218: 13.82
+	Hs
		412039 TYK2_HUMAN (38-1132): 0: 876: 35.94		FYN_HUMAN (394-701): 1.38e-56: 204: 13.64
+	Hs
		442789 ABL2_HUMAN (793-1126): 4.25e-96: 334: 30.45		HCK_HUMAN (372-701): 1.83e-61: 217: 14.88
+	Hs
		522840 ABL2_HUMAN (793-1126): 4.25e-96: 334: 30.45		SRC_HUMAN (391-701): 3.04e-61: 217: 12.54
+	Hs
		412070 ABL2_HUMAN (793-1126): 4.25e-96: 334: 30.45		FYN_HUMAN (394-701): 1.38e-56: 204: 13.64