Protein: SIM2
Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)

Gene: SIM2
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q14190

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693311

ARNT
Aryl hydrocarbon receptor nuclear translocator

7

20

Small-scale

0.970

High

1122914

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

4

20

Small-scale

0.909

High

1122903

FOXR2
Forkhead box protein R2

3

8

High-throughput

0.667

High

461469

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.618

High

468366

HS90B
Heat shock protein HSP 90-beta

1

18

High-throughput

0.618

High

1122901

TEBP
Prostaglandin E synthase 3

2

3

High-throughput

0.614

High

241660

PRKN
E3 ubiquitin-protein ligase parkin

2

6

Small-scale

0.601

High

1122923

MAGD1
Melanoma-associated antigen D1

1

16

Small-scale

0.561

High

1122904

Q6PK50
HSP90AB1 protein

1

18

High-throughput

0.553

High

1122918

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

2

Small-scale

0.552

High

685190

PAX6
Paired box protein Pax-6

1

6

High-throughput

0.541

High

916657

PPP5
Serine/threonine-protein phosphatase 5

1

8

High-throughput

0.541

High

186850

FOXN1
Forkhead box protein N1

1

8

High-throughput

0.536

High

537144

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.536

High

1122916

DNJB4
DnaJ homolog subfamily B member 4

1

9

High-throughput

0.536

High

1122915

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

4

High-throughput

0.494

High

1122917

ADDG
Gamma-adducin

1

1

High-throughput

0.494

High

124777

AIP
AH receptor-interacting protein

1

11

High-throughput

0.479

High

142992

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

226770

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

12

High-throughput

0.479

High

473983

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

799102

BRCA1
Breast cancer type 1 susceptibility protein

1

8

Small-scale

0.479

High

946104

MLF1
Myeloid leukemia factor 1

1

4

High-throughput

0.479

High

1087736

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1097977

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.479

High

1102159

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.479

High

1105917

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

8

High-throughput

0.479

High

1122900

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1122908

CIC
Protein capicua homolog

1

19

High-throughput

0.479

High

1122912

Q9HAV2
Heat shock transcription factor 1

1

1

High-throughput

0.479

High

1122920

CHIP
E3 ubiquitin-protein ligase CHIP

1

13

High-throughput

0.479

High

1122921

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

1122922

ARI1
E3 ubiquitin-protein ligase ARIH1

1

5

Small-scale

0.479

High

1122913

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

76524

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

2

High-throughput

0.437

High

336665

BAG4
BAG family molecular chaperone regulator 4

1

2

High-throughput

0.437

High

347016

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.437

High

415562

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.437

High

731287

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.437

High

846293

MATR3
Matrin-3

1

2

Small-scale

0.437

High

1122902

MLF2
Myeloid leukemia factor 2

1

4

High-throughput

0.437

High

1122905

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.437

High

1122907

Q96BE0
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.437

High

1122909

TTC1
Tetratricopeptide repeat protein 1

1

10

High-throughput

0.437

High

1122910

Q9BPW0
Serine/threonine-protein phosphatase

1

8

High-throughput

0.437

High

1122919

FKBPL
FK506-binding protein-like

1

7

High-throughput

0.437

High

1122906

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

0

High-throughput

0.282

High

1122911

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025