Protein: ARNT
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)

Gene: ARNT
Organism: Homo sapiens
Interactions: 219
UniProt ID: P27540

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001666 - response to hypoxia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693329

HIF1A
Hypoxia-inducible factor 1-alpha

63

20

Small-scale

0.997

High

693256

AHR
Aryl hydrocarbon receptor

29

20

Small-scale

0.992

High

693356

EPAS1
Endothelial PAS domain-containing protein 1

16

20

Small-scale

0.987

High

693311

SIM2
Single-minded homolog 2

7

20

Small-scale

0.970

High

693237

ARNT
Aryl hydrocarbon receptor nuclear translocator

5

20

Small-scale

0.907

High

693381

HIF3A
Hypoxia-inducible factor 3-alpha

3

20

Small-scale

0.855

High

693354

NPAS1
Neuronal PAS domain-containing protein 1

3

20

High-throughput

0.855

High

693288

SIM1
Single-minded homolog 1

3

20

Small-scale

0.849

High

693323

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.800

High

693337

NPAS4
Neuronal PAS domain-containing protein 4

2

20

Small-scale

0.767

High

693325

NCOA1
Nuclear receptor coactivator 1

1

20

Small-scale

0.740

High

72593

AHRR
Aryl hydrocarbon receptor repressor

1

20

Small-scale

0.713

High

693332

FOXR2
Forkhead box protein R2

4

7

High-throughput

0.699

High

693338

NPAS3
Neuronal PAS domain-containing protein 3

1

20

High-throughput

0.691

High

693355

NPAS2
Neuronal PAS domain-containing protein 2

1

20

Small-scale

0.680

High

536548

HSP7C
Heat shock cognate 71 kDa protein

3

8

High-throughput

0.667

High

693246

AKT1
RAC-alpha serine/threonine-protein kinase

3

7

Small-scale

0.665

High

371221

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.647

High

693385

TACC3
Transforming acidic coiled-coil-containing protein 3

2

20

Small-scale

0.643

High

693277

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

3

0

High-throughput

0.638

High

693268

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

14

Small-scale

0.629

High

693248

GLYC
Serine hydroxymethyltransferase, cytosolic

2

1

High-throughput

0.628

High

693374

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

2

11

Small-scale

0.625

High

192899

CLOCK
Circadian locomoter output cycles protein kaput

1

20

Small-scale

0.621

High

693375

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

7

Small-scale

0.621

High

693383

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

7

Small-scale

0.621

High

209953

CRX
Cone-rod homeobox protein

1

7

High-throughput

0.618

High

662201

PAX7
Paired box protein Pax-7

1

6

High-throughput

0.618

High

693279

GSC
Homeobox protein goosecoid

1

9

High-throughput

0.618

High

693367

NANOG
Homeobox protein NANOG

1

8

Small-scale

0.618

High

693365

EGLN3
Prolyl hydroxylase EGLN3

2

14

Small-scale

0.611

High

693371

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

2

1

Small-scale

0.611

High

693324

TRIPB
Thyroid receptor-interacting protein 11

3

8

Small-scale

0.609

High

395531

ESR1
Estrogen receptor

2

20

Small-scale

0.602

High

693357

SLX1
Structure-specific endonuclease subunit SLX1

2

0

High-throughput

0.602

High

693364

CIAO3
Cytosolic iron-sulfur assembly component 3

2

0

High-throughput

0.602

High

413237

P53
Cellular tumor antigen p53

2

7

High-throughput

0.595

High

693242

PML
Protein PML

2

11

Small-scale

0.595

High

693249

CTNB1
Catenin beta-1

2

20

Small-scale

0.584

High

693297

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

693307

CUL2
Cullin-2

2

8

Small-scale

0.584

High

693321

ELOB
Elongin-B

2

2

Small-scale

0.584

High

693362

EGLN1
Egl nine homolog 1

2

14

Small-scale

0.584

High

693260

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.573

High

693343

NCOA7
Nuclear receptor coactivator 7

1

1

Small-scale

0.569

High

693384

NCOR2
Nuclear receptor corepressor 2

1

5

Small-scale

0.569

High

693258

BRCA1
Breast cancer type 1 susceptibility protein

1

7

Small-scale

0.561

High

693271

PAXI
Paxillin

1

5

High-throughput

0.553

High

693352

STRBP
Spermatid perinuclear RNA-binding protein

1

3

High-throughput

0.541

High

693359

MTA3
Metastasis-associated protein MTA3

1

6

High-throughput

0.541

High

642513

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.537

High

693262

CASP3
Caspase-3

1

3

Small-scale

0.536

High

693278

CASP9
Caspase-9

1

3

Small-scale

0.536

High

186836

FOXN1
Forkhead box protein N1

1

7

High-throughput

0.536

High

593025

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.536

High

692653

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.536

High

693276

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

693303

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

693344

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

3

High-throughput

0.536

High

693358

FEM1A
Protein fem-1 homolog A

1

1

High-throughput

0.536

High

693363

SHRPN
Sharpin

1

1

High-throughput

0.536

High

693376

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

1

High-throughput

0.536

High

284283

GEMI
Geminin

1

0

High-throughput

0.518

High

693372

IRAK4
Interleukin-1 receptor-associated kinase 4

1

0

High-throughput

0.518

High

181857

SMAD9
Mothers against decapentaplegic homolog 9

1

6

High-throughput

0.508

High

124738

AIP
AH receptor-interacting protein

1

11

Small-scale

0.501

High

138630

IMA4
Importin subunit alpha-4

1

14

Small-scale

0.501

High

179027

IMA6
Importin subunit alpha-6

1

14

Small-scale

0.501

High

253585

IMA7
Importin subunit alpha-7

1

14

Small-scale

0.501

High

400316

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.501

High

410639

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.501

High

464823

SP1
Transcription factor Sp1

1

7

Small-scale

0.501

High

549056

CDK4
Cyclin-dependent kinase 4

1

8

High-throughput

0.501

High

569057

T2FB
General transcription factor IIF subunit 2

1

1

Small-scale

0.501

High

571178

HGF
Hepatocyte growth factor

1

3

High-throughput

0.501

High

593281

PGFRA
Platelet-derived growth factor receptor alpha

1

4

High-throughput

0.501

High

693244

CCND2
G1/S-specific cyclin-D2

1

3

High-throughput

0.501

High

693250

MERL
Merlin

1

3

High-throughput

0.501

High

693252

T2FA
General transcription factor IIF subunit 1

1

3

Small-scale

0.501

High

693263

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

6

High-throughput

0.501

High

693264

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

6

High-throughput

0.501

High

693265

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

6

High-throughput

0.501

High

693275

IMA5
Importin subunit alpha-5

1

14

Small-scale

0.501

High

693290

CDK6
Cyclin-dependent kinase 6

1

8

High-throughput

0.501

High

693293

TF65
Transcription factor p65

1

10

High-throughput

0.501

High

693300

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

13

High-throughput

0.501

High

693310

TBB2A
Tubulin beta-2A chain

1

4

Small-scale

0.501

High

693318

TEBP
Prostaglandin E synthase 3

1

3

Small-scale

0.501

High

693322

TEAD2
Transcriptional enhancer factor TEF-4

1

1

High-throughput

0.501

High

693326

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.501

High

693328

MK14
Mitogen-activated protein kinase 14

1

4

High-throughput

0.501

High

693340

GLIS1
Zinc finger protein GLIS1

1

4

High-throughput

0.501

High

693361

GLIS2
Zinc finger protein GLIS2

1

2

High-throughput

0.501

High

693370

LATS2
Serine/threonine-protein kinase LATS2

1

9

High-throughput

0.501

High

693377

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.501

High

346864

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.489

High

387100

TNNC2
Troponin C, skeletal muscle

1

2

High-throughput

0.489

High

425879

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.489

High

693309

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

2

High-throughput

0.481

High

693339

ARL14
ADP-ribosylation factor-like protein 14

1

3

High-throughput

0.481

High

666942

CCNE1
G1/S-specific cyclin-E1

1

0

High-throughput

0.480

High

693314

BECN1
Beclin-1

1

0

High-throughput

0.480

High

123595

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.479

High

142846

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

227803

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.479

High

243548

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

10

High-throughput

0.479

High

244537

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

3

High-throughput

0.479

High

255575

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

1

High-throughput

0.479

High

258769

DNJA2
DnaJ homolog subfamily A member 2

1

12

High-throughput

0.479

High

297755

PIAS2
E3 SUMO-protein ligase PIAS2

1

4

Small-scale

0.479

High

341525

EYA4
Protein phosphatase EYA4

1

3

High-throughput

0.479

High

342753

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.479

High

375198

RASK
GTPase KRas

1

3

High-throughput

0.479

High

378473

IL1A
Interleukin-1 alpha

1

1

Small-scale

0.479

High

415362

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.479

High

418600

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

3

High-throughput

0.479

High

424139

S10A8
Protein S100-A8

1

5

High-throughput

0.479

High

429342

JUN
Transcription factor Jun

1

13

Small-scale

0.479

High

440385

FYN
Tyrosine-protein kinase Fyn

1

6

High-throughput

0.479

High

442602

RB
Retinoblastoma-associated protein

1

3

Small-scale

0.479

High

444904

S10A9
Protein S100-A9

1

5

High-throughput

0.479

High

461172

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.479

High

463347

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

473800

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

481104

HMGB1
High mobility group protein B1

1

15

High-throughput

0.479

High

519761

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

532378

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

557878

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

577625

PLAK
Junction plakoglobin

1

19

Small-scale

0.479

High

683385

IKBA
NF-kappa-B inhibitor alpha

1

4

Small-scale

0.479

High

693239

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.479

High

693243

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.479

High

693247

1433S
14-3-3 protein sigma

1

4

High-throughput

0.479

High

693253

MYH9
Myosin-9

1

8

High-throughput

0.479

High

693254

MYH10
Myosin-10

1

8

High-throughput

0.479

High

693255

SOX6
Transcription factor SOX-6

1

19

High-throughput

0.479

High

693259

VHL
von Hippel-Lindau disease tumor suppressor

1

8

High-throughput

0.479

High

693266

MATR3
Matrin-3

1

3

High-throughput

0.479

High

693267

RANG
Ran-specific GTPase-activating protein

1

3

High-throughput

0.479

High

693269

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.479

High

693270

SOX2
Transcription factor SOX-2

1

16

High-throughput

0.479

High

693272

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

693273

DYN2
Dynamin-2

1

1

High-throughput

0.479

High

693274

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

693281

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.479

High

693282

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

High-throughput

0.479

High

693284

H4
Histone H4

1

5

High-throughput

0.479

High

693285

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

High-throughput

0.479

High

693286

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.479

High

693287

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

3

High-throughput

0.479

High

693291

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

5

High-throughput

0.479

High

693294

TLE3
Transducin-like enhancer protein 3

1

9

High-throughput

0.479

High

693295

RL18
Large ribosomal subunit protein eL18

1

1

High-throughput

0.479

High

693296

KLC1
Kinesin light chain 1

1

2

High-throughput

0.479

High

693298

FOXO1
Forkhead box protein O1

1

12

High-throughput

0.479

High

693299

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

693301

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.479

High

693304

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.479

High

693305

SMAD4
Mothers against decapentaplegic homolog 4

1

6

Small-scale

0.479

High

693306

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.479

High

693308

CUL4A
Cullin-4A

1

8

Small-scale

0.479

High

693312

SRC8
Src substrate cortactin

1

3

High-throughput

0.479

High

693315

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

Small-scale

0.479

High

693316

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

693319

NONO
Non-POU domain-containing octamer-binding protein

1

6

High-throughput

0.479

High

693320

ELOC
Elongin-C

1

2

High-throughput

0.479

High

693327

DDB1
DNA damage-binding protein 1

1

7

Small-scale

0.479

High

693335

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

693336

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

8

High-throughput

0.479

High

693341

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

693345

SP7
Transcription factor Sp7

1

7

High-throughput

0.479

High

693346

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

693347

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

693348

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

693349

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

693350

EGLN2
Prolyl hydroxylase EGLN2

1

14

Small-scale

0.479

High

693351

CIC
Protein capicua homolog

1

18

High-throughput

0.479

High

693353

FEV
Protein FEV

1

11

High-throughput

0.479

High

693373

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

693378

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

693379

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

693382

SGT1
Protein SGT1 homolog

1

8

High-throughput

0.479

High

693386

NEMO
NF-kappa-B essential modulator

1

13

Small-scale

0.479

High

344511

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.460

High

179306

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.458

High

595688

H13
Histone H1.3

1

0

High-throughput

0.458

High

611771

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

612511

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

693238

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

693245

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

693251

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

693257

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

693261

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

693283

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.458

High

693289

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

693292

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.458

High

693317

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

693366

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

Small-scale

0.458

High

693368

RTN4
Reticulon-4

1

0

High-throughput

0.458

High

693380

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

648425

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.457

High

693241

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.457

High

693280

MYL6
Myosin light polypeptide 6

1

3

High-throughput

0.437

High

693313

FLOT2
Flotillin-2

1

1

High-throughput

0.437

High

693331

TENS3
Tensin-3

1

4

High-throughput

0.437

High

693333

MPRIP
Myosin phosphatase Rho-interacting protein

1

10

High-throughput

0.437

High

693342

OR6K3
Olfactory receptor 6K3

1

1

High-throughput

0.437

High

693360

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

0

High-throughput

0.347

High

693330

DCA15
DDB1- and CUL4-associated factor 15

3

0

Small-scale

0.342

High

548850

ADHX
Alcohol dehydrogenase class-3

1

0

High-throughput

0.282

High

693369

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.282

High

238698

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.279

Low

485927

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

693240

LYOX
Protein-lysine 6-oxidase

1

0

High-throughput

0.279

Low

693302

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

693334

BOP
Protein Bop

1

0

High-throughput

0.279

Low

591227

CD44
CD44 antigen

1

0

High-throughput

0.261

Low

220656

SYT7
Synaptotagmin-7

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025