Protein: AHR
Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76)

Gene: AHR
Organism: Homo sapiens
Interactions: 129
UniProt ID: P35869

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001094 - TFIID-class transcription factor complex binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693256

ARNT
Aryl hydrocarbon receptor nuclear translocator

29

20

Small-scale

0.992

High

461212

HS90A
Heat shock protein HSP 90-alpha

5

17

Small-scale

0.922

High

777289

NCOA1
Nuclear receptor coactivator 1

2

20

Small-scale

0.821

High

777285

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.768

High

124743

AIP
AH receptor-interacting protein

8

11

Small-scale

0.750

High

395605

ESR1
Estrogen receptor

7

20

Small-scale

0.748

High

442619

RB
Retinoblastoma-associated protein

4

3

Small-scale

0.713

High

764489

CTNB1
Catenin beta-1

4

20

Small-scale

0.683

High

777337

NCOR2
Nuclear receptor corepressor 2

3

9

Small-scale

0.680

High

132703

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

19

Small-scale

0.680

High

777252

AHR
Aryl hydrocarbon receptor

1

20

Small-scale

0.647

High

777325

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

20

Small-scale

0.647

High

777268

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.636

High

777257

NRIP1
Nuclear receptor-interacting protein 1

2

1

Small-scale

0.629

High

777304

TSYL6
Testis-specific Y-encoded-like protein 6

2

2

High-throughput

0.628

High

777254

BRCA1
Breast cancer type 1 susceptibility protein

2

13

Small-scale

0.624

High

777283

TEBP
Prostaglandin E synthase 3

2

3

Small-scale

0.619

High

777277

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.618

High

777292

DDB1
DNA damage-binding protein 1

2

7

Small-scale

0.611

High

522808

COT1
COUP transcription factor 1

2

20

Small-scale

0.602

High

628718

TBP
TATA-box-binding protein

2

1

Small-scale

0.602

High

777321

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

777266

RELB
Transcription factor RelB

2

11

Small-scale

0.601

High

777332

CHIP
E3 ubiquitin-protein ligase CHIP

2

13

Small-scale

0.595

High

172518

XPO1
Exportin-1

2

8

Small-scale

0.584

High

282167

MAF
Transcription factor Maf

2

3

Small-scale

0.584

High

777267

TF65
Transcription factor p65

2

11

Small-scale

0.584

High

251525

CCNT1
Cyclin-T1

1

2

Small-scale

0.573

High

777305

NCOA7
Nuclear receptor coactivator 7

1

1

Small-scale

0.569

High

777269

TBL3
Transducin beta-like protein 3

1

5

Small-scale

0.561

High

777276

CUL4B
Cullin-4B

1

9

Small-scale

0.561

High

777290

NEDD8
Ubiquitin-like protein NEDD8

1

1

Small-scale

0.561

High

777334

TN13B
Tumor necrosis factor ligand superfamily member 13B

2

0

Small-scale

0.559

High

171190

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

2

High-throughput

0.536

High

258786

DNJA2
DnaJ homolog subfamily A member 2

1

11

High-throughput

0.536

High

270780

ROCK2
Rho-associated protein kinase 2

1

5

High-throughput

0.536

High

777273

ROCK1
Rho-associated protein kinase 1

1

4

High-throughput

0.536

High

777281

NAA25
N-alpha-acetyltransferase 25, NatB auxiliary subunit

1

2

High-throughput

0.536

High

777284

SF3B3
Splicing factor 3B subunit 3

1

7

High-throughput

0.536

High

777286

CIP4
Cdc42-interacting protein 4

1

2

High-throughput

0.536

High

777288

TOM34
Mitochondrial import receptor subunit TOM34

1

10

High-throughput

0.536

High

777297

ARH
Low density lipoprotein receptor adapter protein 1

1

3

High-throughput

0.536

High

777302

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

3

High-throughput

0.536

High

777303

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.536

High

777311

TRI52
E3 ubiquitin-protein ligase TRIM52

1

8

High-throughput

0.536

High

777315

PPM1M
Protein phosphatase 1M

1

1

High-throughput

0.536

High

777318

VRK1
Serine/threonine-protein kinase VRK1

1

6

High-throughput

0.536

High

777320

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

2

High-throughput

0.536

High

777324

SH24A
SH2 domain-containing protein 4A

1

1

High-throughput

0.536

High

777326

CHM1A
Charged multivesicular body protein 1a

1

2

High-throughput

0.536

High

777327

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.536

High

777330

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

777336

CHMP3
Charged multivesicular body protein 3

1

2

High-throughput

0.536

High

777338

STK24
Serine/threonine-protein kinase 24

1

8

High-throughput

0.536

High

49291

SHOT1
Shootin-1

1

0

High-throughput

0.513

High

186364

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.513

High

295298

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.513

High

777299

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.513

High

777307

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.513

High

777309

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.513

High

777310

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.513

High

777312

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

777316

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.513

High

777317

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

777333

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.513

High

777335

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

130708

TAF4
Transcription initiation factor TFIID subunit 4

1

6

Small-scale

0.501

High

464847

SP1
Transcription factor Sp1

1

12

Small-scale

0.501

High

557142

SRC
Proto-oncogene tyrosine-protein kinase Src

1

5

Small-scale

0.501

High

569069

T2FB
General transcription factor IIF subunit 2

1

1

Small-scale

0.501

High

770345

T2FA
General transcription factor IIF subunit 1

1

4

Small-scale

0.501

High

777259

RT29
Small ribosomal subunit protein mS29

1

1

Small-scale

0.501

High

777260

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

8

Small-scale

0.501

High

777293

TAF9
Transcription initiation factor TFIID subunit 9

1

2

Small-scale

0.501

High

777263

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.493

High

427817

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.489

High

706080

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

777306

KLDC4
Kelch domain-containing protein 4

1

4

High-throughput

0.489

High

777314

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.489

High

777339

NS1BP
Influenza virus NS1A-binding protein

1

4

Small-scale

0.481

High

777258

TAF6
Transcription initiation factor TFIID subunit 6

1

0

Small-scale

0.480

High

142872

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

174492

TRI66
Tripartite motif-containing protein 66

1

15

High-throughput

0.479

High

210876

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

400393

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

473826

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487024

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

519796

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

536624

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

583826

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.479

High

610246

PRS6A
26S proteasome regulatory subunit 6A

1

13

Small-scale

0.479

High

777253

PRS7
26S proteasome regulatory subunit 7

1

6

Small-scale

0.479

High

777256

PRS6B
26S proteasome regulatory subunit 6B

1

6

Small-scale

0.479

High

777264

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

777265

E2F1
Transcription factor E2F1

1

3

Small-scale

0.479

High

777270

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

777274

SMAD4
Mothers against decapentaplegic homolog 4

1

9

Small-scale

0.479

High

777275

CUL3
Cullin-3

1

9

High-throughput

0.479

High

777278

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

2

Small-scale

0.479

High

777279

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.479

High

777280

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

777282

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

777308

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.479

High

777323

EGLN3
Prolyl hydroxylase EGLN3

1

14

High-throughput

0.479

High

777328

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

777331

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.479

High

216385

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

Small-scale

0.458

High

474519

VIME
Vimentin

1

0

Small-scale

0.458

High

777262

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

777291

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

Small-scale

0.458

High

777295

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

777298

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

777287

MED1
Mediator of RNA polymerase II transcription subunit 1

1

15

Small-scale

0.445

High

518768

IL8
Interleukin-8

1

1

Small-scale

0.437

High

777301

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.407

High

231416

CXL13
C-X-C motif chemokine 13

2

0

Small-scale

0.305

High

777255

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.279

Low

777261

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

777271

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

777272

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

777294

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

777296

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

777300

RWDD4
RWD domain-containing protein 4

1

0

High-throughput

0.279

Low

777313

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.279

Low

777319

CMS1
Protein CMSS1

1

0

High-throughput

0.279

Low

777322

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.279

Low

777329

S18L2
SS18-like protein 2

1

0

High-throughput

0.279

Low

648027

CCL1
C-C motif chemokine 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025