HitPredict

Interactor 1: CD33 (Q63994)
Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (CD antigen CD33)
Gene: CD33

Interactor 2: TLR1 (Q9EPQ1)
Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
Gene: TLR1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~ig, LRR_8~V-set
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 403 Mm			1 795
+	Mm
		1144430 CD33_MOUSE (1-403): 2.62e-150: 433: 100.00		TLR6_MOUSE (16-793): 4.41e-116: 371: 65.55
+	Mm
		1144432 CD33_MOUSE (1-403): 2.62e-150: 433: 100.00		TLR2_MOUSE (4-781): 3.13e-100: 329: 28.43
+	Mm
		1144428 CD33_MOUSE (1-403): 2.62e-150: 433: 100.00		TLR3_MOUSE (2-784): 1.83e-73: 259: 17.86
+	Hs
		177599 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR1_HUMAN (4-788): 2.87e-126: 398: 73.89
+	Mm
		1265315 SIGL5_MOUSE (1-325): 2.65e-61: 209: 41.47		TLR1_MOUSE (1-795): 1.38e-128: 404: 100.00
+	Hs
		177614 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR6_HUMAN (17-791): 1.13e-117: 376: 59.87
+	Hs
		589580 CD33_HUMAN (11-307): 8.52e-71: 228: 47.62		TLR10_HUMAN (5-788): 6.53e-105: 342: 46.82
+	Hs
		177605 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR10_HUMAN (5-788): 6.53e-105: 342: 46.82
+	Mm
		1265318 SIGL5_MOUSE (1-325): 2.65e-61: 209: 41.47		TLR2_MOUSE (4-781): 3.13e-100: 329: 28.43
+	Mm
		1144431 CD33_MOUSE (1-403): 2.62e-150: 433: 100.00		TLR5_MOUSE (4-312): 1.89e-14: 79.6: 13.91
+	Hs
		177610 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR7_HUMAN (28-583): 4.93e-27: 120: 13.45
+	Hs
		237424 CD33_HUMAN (11-307): 8.52e-71: 228: 47.62		TLR5_HUMAN (4-238): 2.74e-16: 85.4: 14.77
+	Hs
		177591 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR5_HUMAN (4-238): 2.74e-16: 85.4: 14.77
+	Hs
		177589 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR3_HUMAN (260-561): 8.69e-15: 80.8: 12.58
+	Hs
		120112 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR4_HUMAN (1-440): 1.1e-14: 80.4: 12.36
+	Hs
		177607 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR9_HUMAN (191-527): 6.14e-13: 75: 13.60
+	Hs
		177608 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR8_HUMAN (261-554): 1.7e-12: 73.4: 13.17
+	Mm
		1265316 SIGL5_MOUSE (1-325): 2.65e-61: 209: 41.47		TLR5_MOUSE (4-312): 1.89e-14: 79.6: 13.91
+	Hs
		177592 SIGL5_HUMAN (11-375): 1.57e-65: 220: 34.30		TLR2_HUMAN (252-531): 1.37e-09: 63.8: 12.33
+	Mm
		1265317 SIGL5_MOUSE (1-325): 2.65e-61: 209: 41.47		TLR4_MOUSE (227-522): 1.37e-09: 63.8: 12.16