HitPredict

Interactor 1: CP135 (Q66GS9)
Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4)
Gene: CEP135

Interactor 2: CP250 (Q9BV73)
Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2)
Gene: CEP250

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33961781, 34079125, 34349018
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005814 - centriole GO:0005829 - cytosol GO:0010457 - centriole-centriole cohesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 2442
+	Hs
		1113839 GRDN_HUMAN (100-1138): 1.23e-43: 176: 11.61		CP250_HUMAN (1-2442): 2.19e-172: 592: 100.00
+	Hs
		725179 CP135_HUMAN (1-1140): 1.31e-85: 303: 100.00		MYH10_HUMAN (1424-2376): 3.63e-37: 157: 13.43
+	Hs
		1145905 CP135_HUMAN (1-1140): 1.31e-85: 303: 100.00		AKAP9_HUMAN (2-1515): 4.1e-26: 120: 11.62
+	Hs
		1059229 CP135_HUMAN (1-1140): 1.31e-85: 303: 100.00		GOGB1_HUMAN (1634-2442): 3.53e-19: 97.7: 11.58
+	Hs
		1068548 GRDN_HUMAN (100-1138): 1.23e-43: 176: 11.61		PLEC_HUMAN (3-1489): 1.72e-44: 181: 13.02
+	Hs
		725097 MYH11_HUMAN (417-1140): 5.39e-44: 177: 15.36		MYH10_HUMAN (1424-2376): 3.63e-37: 157: 13.43
+	Hs
		725095 MYH10_HUMAN (410-1140): 1.54e-40: 166: 13.95		MYH10_HUMAN (1424-2376): 3.63e-37: 157: 13.43
+	Hs
		528435 MYH8_HUMAN (417-1140): 2.53e-39: 162: 14.25		MYH4_HUMAN (1-882): 5.16e-36: 153: 14.25
+	Hs
		528356 MYH6_HUMAN (382-1137): 2.97e-37: 155: 12.55		MYH6_HUMAN (772-1881): 8.18e-38: 158: 13.02
+	Dm
		1229141 CL190_DROME (1-873): 6e-39: 160: 12.15		LVA_DROME (1160-2442): 1.45e-33: 145: 12.08
+	Rn
		361106 MYH6_RAT (474-1128): 1.63e-33: 143: 14.31		MYH6_RAT (772-1881): 6.62e-38: 159: 13.11
+	Hs
		502933 MYH3_HUMAN (474-1140): 7.75e-35: 147: 14.20		MYH4_HUMAN (1-882): 5.16e-36: 153: 14.25
+	Hs
		502901 MYH6_HUMAN (382-1137): 2.97e-37: 155: 12.55		MYH3_HUMAN (2-844): 3.25e-33: 143: 11.40
+	Hs
		522585 MYH7_HUMAN (588-1139): 1.75e-29: 129: 11.94		MYH7_HUMAN (2-831): 2.26e-36: 154: 12.28
+	Hs
		148466 MYH11_HUMAN (417-1140): 5.39e-44: 177: 15.36		CTRO_HUMAN (633-1361): 7.89e-09: 63.5: 21.55
+	Hs
		528432 MYH8_HUMAN (417-1140): 2.53e-39: 162: 14.25		MYH13_HUMAN (27-621): 4.59e-10: 67.8: 13.95
+	Hs
		148461 MYH10_HUMAN (410-1140): 1.54e-40: 166: 13.95		CTRO_HUMAN (633-1361): 7.89e-09: 63.5: 21.55