HitPredict

Interactor 1: E4F1 (Q66K89)
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
Gene: E4F1

Interactor 2: VWCE (Q96DN2)
von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)
Gene: VWCE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 784 Hs			1 955
+	Hs
		980401 E4F1_HUMAN (1-784): 0: 590: 100.00		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		1016966 E4F1_HUMAN (1-784): 0: 590: 100.00		FBLN3_HUMAN (46-217): 4.18e-18: 90.6: 25.26
+	Hs
		565090 ZNF7_HUMAN (194-615): 5.25e-119: 376: 24.48		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		980435 ZN761_HUMAN (2-298): 3.8e-105: 341: 17.69		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		477789 ZN888_HUMAN (24-345): 1.28e-91: 304: 16.72		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		980570 ZN107_HUMAN (2-172): 4.29e-52: 196: 9.44		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		980500 ZN594_HUMAN (3-125): 9.43e-30: 128: 10.00		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		980558 RBAK_HUMAN (192-269): 2.29e-13: 75.9: 42.31		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		980498 ZN419_HUMAN (192-271): 1.48e-10: 66.2: 41.25		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		1138087 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21
+	Hs
		957284 ZN594_HUMAN (3-125): 9.43e-30: 128: 10.00		FBLN2_HUMAN (181-300): 7.32e-10: 65.2: 25.64
+	Hs
		612865 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		FBLN1_HUMAN (149-534): 1.88e-20: 99.1: 18.80
+	Hs
		1016965 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		FBLN3_HUMAN (46-217): 4.18e-18: 90.6: 25.26
+	Hs
		328061 RBAK_HUMAN (192-269): 2.29e-13: 75.9: 42.31		FBLN4_HUMAN (125-261): 4.01e-14: 77.8: 37.59
+	Hs
		804266 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		NOTC1_HUMAN (6-391): 9.43e-14: 78.2: 11.19
+	Hs
		328002 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		FBLN4_HUMAN (125-261): 4.01e-14: 77.8: 37.59
+	Hs
		254234 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		MEGF6_HUMAN (281-832): 1.03e-11: 71.3: 9.26
+	Hs
		254280 ZN248_HUMAN (192-271): 7.05e-12: 70.9: 42.50		LRP4_HUMAN (69-233): 5.88e-09: 62.5: 18.44
+	Hs
		1138075 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		NELL2_HUMAN (386-747): 4.84e-11: 68.7: 19.18
+	Hs
		1138066 GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00		NELL1_HUMAN (386-746): 8.55e-11: 67.9: 19.77