HitPredict

Interactor 1: TWF2 (Q6IBS0)
Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)
Gene: TWF2

Interactor 2: ARP3B (Q9P1U1)
Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)
Gene: ACTR3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0051015 - actin filament binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 349 Hs			1 418
+	Hs
		896732 TWF1_HUMAN (1-344): 4.14e-154: 438: 65.41		ARP3_HUMAN (1-418): 0: 571: 90.67
+	Hs
		891834 TWF2_HUMAN (1-349): 1.13e-170: 480: 100.00		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		929897 TWF2_HUMAN (1-349): 1.13e-170: 480: 100.00		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Hs
		932210 TWF2_HUMAN (1-349): 1.13e-170: 480: 100.00		ACTC_HUMAN (3-414): 0: 518: 35.84
+	Hs
		915411 TWF2_HUMAN (1-349): 1.13e-170: 480: 100.00		ACTA_HUMAN (3-414): 0: 517: 35.84
+	Hs
		891728 TWF1_HUMAN (1-344): 4.14e-154: 438: 65.41		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		929835 TWF1_HUMAN (1-344): 4.14e-154: 438: 65.41		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Hs
		932122 TWF1_HUMAN (1-344): 4.14e-154: 438: 65.41		ACTC_HUMAN (3-414): 0: 518: 35.84
+	Dm
		501533 TWF_DROME (1-345): 1.83e-144: 413: 49.57		ACT1_DROME (3-414): 0: 523: 35.11
+	Sc
		860511 TWF1_YEAST (1-333): 4.59e-80: 249: 24.58		ACT_YEAST (1-414): 0: 521: 34.46
+	At
		477717 ADF6_ARATH (2-139): 2.53e-53: 174: 22.46		ACT3_ARATH (2-414): 0: 516: 35.27
+	At
		862533 ADF6_ARATH (2-139): 2.53e-53: 174: 22.46		ACT7_ARATH (2-414): 0: 516: 35.51
+	Sc
		887656 COFI_YEAST (1-142): 1.82e-47: 159: 21.68		ACT_YEAST (1-414): 0: 521: 34.46
+	Hs
		891649 DEST_HUMAN (3-138): 2.92e-40: 141: 21.29		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		891650 GMFB_HUMAN (178-312): 1.08e-40: 141: 22.14		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		894652 DEST_HUMAN (3-138): 2.92e-40: 141: 21.29		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Hs
		894665 DEST_HUMAN (3-138): 2.92e-40: 141: 21.29		Q1KLZ0_HUMAN (1-414): 0: 528: 35.42
+	Hs
		894697 GMFB_HUMAN (178-312): 1.08e-40: 141: 22.14		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Ce
		501473 ADF1_CAEEL (4-189): 3.24e-40: 142: 18.66		ACT4_CAEEL (3-414): 0: 526: 35.59
+	Hs
		894651 DEST_HUMAN (3-138): 2.92e-40: 141: 21.29		ACTA_HUMAN (3-414): 0: 517: 35.84