Protein: U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)

Gene: U2AFM, ZRSR2
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q15696

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex
GO:0005689 - U12-type spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006427

SRPK2
SRSF protein kinase 2

9

9

High-throughput

0.976

High

1152347

SRPK1
SRSF protein kinase 1

4

9

High-throughput

0.906

High

889573

CLK2
Dual specificity protein kinase CLK2

4

3

High-throughput

0.904

High

1152344

SPF45
Splicing factor 45

4

11

High-throughput

0.892

High

175693

SR140
U2 snRNP-associated SURP motif-containing protein

3

1

High-throughput

0.861

High

913943

RBM5
RNA-binding protein 5

3

2

High-throughput

0.861

High

1105298

SF3B2
Splicing factor 3B subunit 2

3

1

High-throughput

0.861

High

1152327

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

3

6

High-throughput

0.861

High

1152340

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

3

5

High-throughput

0.861

High

1152345

RNPC3
RNA-binding region-containing protein 3

3

1

High-throughput

0.861

High

285937

SF3B1
Splicing factor 3B subunit 1

4

0

High-throughput

0.857

High

1152321

U2AFL
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

3

7

High-throughput

0.818

High

1088674

SF3A3
Splicing factor 3A subunit 3

3

0

High-throughput

0.816

High

1152354

ZMAT5
Zinc finger matrin-type protein 5

3

0

High-throughput

0.816

High

1099089

SRSF5
Serine/arginine-rich splicing factor 5

2

6

High-throughput

0.783

High

1152326

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

2

8

High-throughput

0.783

High

719549

NKTR
NK-tumor recognition protein

3

2

High-throughput

0.770

High

636086

CD11B
Cyclin-dependent kinase 11B

2

2

High-throughput

0.705

High

1152350

SDCB2
Syntenin-2

4

1

High-throughput

0.698

High

1152360

SF3B6
Splicing factor 3B subunit 6

1

4

High-throughput

0.691

High

973928

RUXF
Small nuclear ribonucleoprotein F

3

1

High-throughput

0.675

High

1058035

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

3

1

High-throughput

0.667

High

1149072

SF3A1
Splicing factor 3A subunit 1

3

2

High-throughput

0.667

High

1152331

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

2

High-throughput

0.667

High

1152337

CHERP
Calcium homeostasis endoplasmic reticulum protein

3

4

High-throughput

0.667

High

1147889

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.656

High

67829

SRRM4
Serine/arginine repetitive matrix protein 4

3

2

High-throughput

0.654

High

1152330

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

3

0

High-throughput

0.638

High

1152338

PDCD7
Programmed cell death protein 7

3

0

High-throughput

0.638

High

1152348

NADAP
Kanadaptin

3

0

High-throughput

0.638

High

973730

RUXE
Small nuclear ribonucleoprotein E

3

0

High-throughput

0.634

High

574287

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

2

High-throughput

0.628

High

991186

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

5

High-throughput

0.628

High

1060997

SRSF1
Serine/arginine-rich splicing factor 1

1

6

High-throughput

0.621

High

974137

RUXG
Small nuclear ribonucleoprotein G

2

4

High-throughput

0.611

High

1152328

SPT2
Protein SPT2 homolog

2

3

High-throughput

0.611

High

1152332

TTC33
Tetratricopeptide repeat protein 33

3

1

High-throughput

0.609

High

1152352

TRPM3
Transient receptor potential cation channel subfamily M member 3

3

1

High-throughput

0.609

High

1152359

LC7L2
Putative RNA-binding protein Luc7-like 2

3

1

High-throughput

0.597

High

1152335

KHDC4
KH homology domain-containing protein 4

2

0

High-throughput

0.580

High

1093111

STK4
Serine/threonine-protein kinase 4

1

3

High-throughput

0.575

High

889427

CLK1
Dual specificity protein kinase CLK1

1

3

High-throughput

0.555

High

1152329

REP15
Rab15 effector protein

2

1

High-throughput

0.553

High

1152342

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

1

High-throughput

0.553

High

974751

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

High-throughput

0.536

High

859296

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

974564

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

1152334

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.513

High

413902

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

904764

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

1152356

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

321548

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.460

High

1152333

RS27L
Ribosomal protein eS27-like

1

0

High-throughput

0.460

High

1152353

SPS2L
SPATS2-like protein

1

0

High-throughput

0.460

High

212249

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

1152349

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.458

High

71582

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

4

High-throughput

0.445

High

1152336

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

1152358

ADIP
Afadin- and alpha-actinin-binding protein

4

0

High-throughput

0.368

High

839555

HUTH
Histidine ammonia-lyase

3

0

High-throughput

0.347

High

895440

SPB8
Serpin B8

3

0

High-throughput

0.347

High

1152339

GPT11
G patch domain-containing protein 11

3

0

High-throughput

0.347

High

1152343

CCD97
Coiled-coil domain-containing protein 97

3

0

High-throughput

0.347

High

1152357

RL26L
Ribosomal protein uL24-like

3

0

High-throughput

0.342

High

1152341

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

2

0

High-throughput

0.316

High

1152346

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.316

High

1152355

CCNL1
Cyclin-L1

2

0

High-throughput

0.316

High

1136215

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

422155

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

960745

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.249

Low

985184

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.249

Low

1152351

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.249

Low

946999

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025