HitPredict

Interactor 1: ZN174 (Q15697)
Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8)
Gene: ZNF174

Interactor 2: ZKSC8 (Q15776)
Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192)
Gene: ZKSCAN8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	10567577, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SCAN~SCAN, zf-C2H2~zf-C2H2
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 407 Hs			1 578
+	Hs
		704472 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		MZF1_HUMAN (99-576): 5.35e-131: 401: 32.14
+	Hs
		517610 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZSC22_HUMAN (399-578): 5.14e-88: 282: 58.33
+	Hs
		517583 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		ZSC22_HUMAN (399-578): 5.14e-88: 282: 58.33
+	Hs
		1380375 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZKSC4_HUMAN (389-577): 2.93e-81: 266: 49.31
+	Hs
		1152378 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		ZKSC4_HUMAN (389-577): 2.93e-81: 266: 49.31
+	Hs
		1491508 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZSC21_HUMAN (402-572): 4.5e-59: 206: 59.06
+	Hs
		1152398 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		ZSC21_HUMAN (402-572): 4.5e-59: 206: 59.06
+	Hs
		1152386 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		ZKSC3_HUMAN (119-403): 5.34e-49: 180: 18.59
+	Hs
		213439 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZSC12_HUMAN (112-349): 1.51e-38: 151: 15.27
+	Hs
		1490817 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZKSC5_HUMAN (458-577): 4.28e-33: 137: 53.33
+	Hs
		1353501 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZN483_HUMAN (110-347): 3.06e-33: 136: 15.79
+	Hs
		1152377 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		ZN483_HUMAN (110-347): 3.06e-33: 136: 15.79
+	Hs
		1292000 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZSC30_HUMAN (172-375): 3.56e-30: 125: 23.25
+	Hs
		1338617 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZN397_HUMAN (29-176): 2.53e-24: 108: 7.64
+	Hs
		1453868 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZKSC7_HUMAN (110-283): 1.32e-23: 107: 10.93
+	Hs
		1152374 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		ZN397_HUMAN (29-176): 2.53e-24: 108: 7.64
+	Hs
		1153692 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZKSC8_HUMAN (541-578): 3.45e-10: 64.5: 52.63
+	Hs
		600457 ZSC21_HUMAN (7-407): 1.82e-132: 390: 29.53		ZKSC1_HUMAN (106-211): 3.77e-09: 61.5: 11.32
+	Hs
		600419 ZN174_HUMAN (1-407): 1.94e-132: 387: 100.00		ZKSC1_HUMAN (106-211): 3.77e-09: 61.5: 11.32
+	Hs
		245030 ZN500_HUMAN (1-406): 1.79e-125: 372: 31.45		ZKSC8_HUMAN (541-578): 3.45e-10: 64.5: 52.63