HitPredict

Interactor 1: NEDD8 (Q15843)
Ubiquitin-like protein NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8)
Gene: NEDD8

Interactor 2: KLH22 (Q53GT1)
Kelch-like protein 22
Gene: KLHL22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	21145461, 37788672
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Kelch_1~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 81 Hs			1 634
+	Hs
		987059 RS27A_HUMAN (1-77): 6.68e-37: 122: 57.14		KLH22_HUMAN (1-634): 2.13e-169: 499: 100.00
+	Hs
		1154907 NEDD8_HUMAN (1-81): 2.08e-30: 103: 100.00		KLH15_HUMAN (29-603): 8.94e-82: 271: 30.54
+	Hs
		1154842 NEDD8_HUMAN (1-81): 2.08e-30: 103: 100.00		KLH12_HUMAN (529-631): 1.19e-13: 76: 13.59
+	Hs
		1154945 NEDD8_HUMAN (1-81): 2.08e-30: 103: 100.00		KLHL9_HUMAN (545-633): 4.58e-11: 68: 12.36