Protein: KLH15
Kelch-like protein 15

Gene: KLH15, KLHL15
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q96M94

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0071630 - nuclear protein quality control by the ubiquitin-proteasome system

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114032

CUL3
Cullin-3

9

20

Small-scale

0.969

High

1397881

KLH13
Kelch-like protein 13

2

19

High-throughput

0.776

High

1154907

NEDD8
Ubiquitin-like protein NEDD8

1

4

High-throughput

0.691

High

1371835

CUL5
Cullin-5

1

20

High-throughput

0.691

High

1272523

CSN6
COP9 signalosome complex subunit 6

3

12

High-throughput

0.675

High

1277104

SAMD7
Sterile alpha motif domain-containing protein 7

3

2

High-throughput

0.667

High

1370305

CSN5
COP9 signalosome complex subunit 5

3

13

High-throughput

0.662

High

1332965

ZN511
Zinc finger protein 511

4

0

High-throughput

0.661

High

1397870

CTIP
DNA endonuclease RBBP8

3

0

Small-scale

0.659

High

1388226

PBIR1
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

3

0

High-throughput

0.638

High

1081193

ELP6
Elongator complex protein 6

3

0

High-throughput

0.634

High

1206881

TOIP1
Torsin-1A-interacting protein 1

3

0

High-throughput

0.634

High

1380403

RNF34
E3 ubiquitin-protein ligase RNF34

2

2

High-throughput

0.628

High

1397880

KLH14
Kelch-like protein 14

1

19

High-throughput

0.618

High

1397865

KLH15
Kelch-like protein 15

1

19

Small-scale

0.618

High

1322345

ZN444
Zinc finger protein 444

2

6

High-throughput

0.611

High

1397886

CSN3
COP9 signalosome complex subunit 3

2

20

High-throughput

0.611

High

647397

IDS
Iduronate 2-sulfatase

3

1

High-throughput

0.609

High

1179267

CB068
UPF0561 protein C2orf68

3

1

High-throughput

0.609

High

1206522

PRC2B
Protein PRRC2B

3

5

High-throughput

0.609

High

1397882

WRP73
WD repeat-containing protein WRAP73

3

2

High-throughput

0.609

High

469693

MMP2
72 kDa type IV collagenase

2

0

High-throughput

0.602

High

1239915

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.602

High

1352072

ELP5
Elongator complex protein 5

2

0

High-throughput

0.602

High

1397866

DMRTB
Doublesex- and mab-3-related transcription factor B1

2

0

High-throughput

0.602

High

1145329

RNPS1
RNA-binding protein with serine-rich domain 1

2

1

High-throughput

0.601

High

1397887

LIMC1
LIM and calponin homology domains-containing protein 1

3

2

High-throughput

0.599

High

1308576

NUDC3
NudC domain-containing protein 3

3

20

High-throughput

0.593

High

1397878

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.576

High

58678

FRMD3
FERM domain-containing protein 3

2

4

High-throughput

0.574

High

641474

CD72
B-cell differentiation antigen CD72

2

3

High-throughput

0.574

High

49511

TLDC2
TLD domain-containing protein 2

1

1

High-throughput

0.536

High

250317

VINEX
Vinexin

1

4

High-throughput

0.536

High

1360279

CSN9
COP9 signalosome complex subunit 9

1

1

High-throughput

0.536

High

1391942

DCNL1
DCN1-like protein 1

1

10

High-throughput

0.536

High

986642

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.513

High

1330998

ZN366
Zinc finger protein 366

1

0

High-throughput

0.513

High

1397871

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

1397890

MTL5
Tesmin

1

0

High-throughput

0.513

High

65641

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

1

1

High-throughput

0.489

High

217506

E41L2
Band 4.1-like protein 2

1

4

High-throughput

0.489

High

1132167

ICAM4
Intercellular adhesion molecule 4

1

2

High-throughput

0.489

High

1152777

KISS1
Metastasis-suppressor KiSS-1

1

3

High-throughput

0.489

High

1160924

PRSS8
Prostasin

1

2

High-throughput

0.489

High

1311017

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.489

High

1340027

GP150
Probable G-protein coupled receptor 150

1

2

High-throughput

0.489

High

1397873

RFIP5
Rab11 family-interacting protein 5

1

1

High-throughput

0.489

High

461821

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

468696

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

983939

RBX1
E3 ubiquitin-protein ligase RBX1

1

8

Small-scale

0.479

High

994341

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.479

High

1397891

ARI1
E3 ubiquitin-protein ligase ARIH1

1

14

High-throughput

0.479

High

176863

DCLK1
Serine/threonine-protein kinase DCLK1

1

8

Small-scale

0.470

High

1116189

FCL
GDP-L-fucose synthase

1

2

High-throughput

0.470

High

1327401

DCLK2
Serine/threonine-protein kinase DCLK2

1

9

Small-scale

0.470

High

717944

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

Small-scale

0.458

High

298949

DNJB5
DnaJ homolog subfamily B member 5

1

11

High-throughput

0.445

High

537724

HSP7C
Heat shock cognate 71 kDa protein

1

11

High-throughput

0.445

High

761487

HS71L
Heat shock 70 kDa protein 1-like

1

11

High-throughput

0.445

High

958697

CSN2
COP9 signalosome complex subunit 2

1

20

High-throughput

0.445

High

1397883

CSN7A
COP9 signalosome complex subunit 7a

1

5

High-throughput

0.445

High

1397885

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.445

High

221280

DCX
Neuronal migration protein doublecortin

1

3

Small-scale

0.437

High

768923

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1336823

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

7

High-throughput

0.437

High

1397872

LZTS2
Leucine zipper putative tumor suppressor 2

1

6

High-throughput

0.437

High

1397875

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1397877

LRC40
Leucine-rich repeat-containing protein 40

1

4

High-throughput

0.437

High

1397888

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

High-throughput

0.437

High

1397889

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.426

High

347258

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.407

High

438038

CO5A2

1

20

High-throughput

0.407

High

551746

COBA1

1

19

High-throughput

0.407

High

635465

CO5A1

1

19

High-throughput

0.407

High

654550

FBLN1
Fibulin-1

1

5

High-throughput

0.407

High

846776

GRK6
G protein-coupled receptor kinase 6

1

5

High-throughput

0.407

High

1055412

NPT2A
Sodium-dependent phosphate transport protein 2A

1

1

High-throughput

0.407

High

1397868

RUFY1
RUN and FYVE domain-containing protein 1

1

6

High-throughput

0.407

High

1397869

DNJC7
DnaJ homolog subfamily C member 7

1

11

High-throughput

0.407

High

1397879

TEN3
Teneurin-3

1

3

High-throughput

0.407

High

1397884

DNJB4
DnaJ homolog subfamily B member 4

1

11

High-throughput

0.407

High

346774

CER1
Cerberus

3

0

High-throughput

0.347

High

567220

PPA5
Tartrate-resistant acid phosphatase type 5

3

0

High-throughput

0.347

High

1397874

BORG4
Cdc42 effector protein 4

3

0

High-throughput

0.347

High

1397892

KPTN
KICSTOR complex protein kaptin

3

0

High-throughput

0.347

High

1038027

CACB1
Voltage-dependent L-type calcium channel subunit beta-1

3

0

High-throughput

0.345

High

1224890

TENS2
Tensin-2

2

0

High-throughput

0.331

High

377069

COLI
Pro-opiomelanocortin

2

0

High-throughput

0.328

High

866442

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

2

0

High-throughput

0.328

High

1187217

CC50B
Cell cycle control protein 50B

2

0

High-throughput

0.328

High

1397867

F161B
Protein FAM161B

2

0

High-throughput

0.328

High

1397876

PAAT
ATPase PAAT

2

0

High-throughput

0.328

High

1023859

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

Small-scale

0.292

High

859950

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.279

Low

1323713

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.279

Low

1328390

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.279

Low

1347781

F110D
Protein FAM110D

1

0

High-throughput

0.279

Low

1355917

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.279

Low

716942

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low

1395378

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025