HitPredict

Interactor 1: CPSF6 (Q6NVF9)
Cleavage and polyadenylation specificity factor subunit 6
Gene: CPSF6

Interactor 2: NONO (Q99K48)
Non-POU domain-containing octamer-binding protein (NonO protein)
Gene: NONO

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	34133714
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0016607 - nuclear speck GO:0042382 - paraspeckles
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Mm			1 473
+	Mm
		1111962 SMCA4_MOUSE (62-551): 3.31e-53: 197: 18.82		NONO_MOUSE (1-473): 2.88e-87: 276: 100.00
+	Hs
		1069746 CPSF7_HUMAN (1-525): 5.21e-54: 191: 40.45		NONO_HUMAN (1-473): 1.65e-86: 274: 98.31
+	Hs
		1084547 CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62		PSPC1_HUMAN (5-471): 8.17e-63: 214: 55.77
+	Hs
		846978 SMCA4_HUMAN (62-551): 5.73e-48: 181: 17.87		NONO_HUMAN (1-473): 1.65e-86: 274: 98.31
+	Hs
		846779 SMCA2_HUMAN (63-551): 3.18e-44: 170: 15.19		NONO_HUMAN (1-473): 1.65e-86: 274: 98.31
+	Mm
		1150292 SMCA2_MOUSE (63-551): 9.15e-42: 163: 13.27		NONO_MOUSE (1-473): 2.88e-87: 276: 100.00
+	Hs
		1077379 CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62		ELAV1_HUMAN (70-207): 2.67e-45: 162: 27.82
+	Hs
		1235754 CPSF7_HUMAN (1-525): 5.21e-54: 191: 40.45		PSPC1_HUMAN (5-471): 8.17e-63: 214: 55.77
+	Mm
		1111957 SMCA4_MOUSE (62-551): 3.31e-53: 197: 18.82		SFPQ_MOUSE (11-473): 3.28e-51: 186: 52.72
+	Hs
		613519 CPSF7_HUMAN (1-525): 5.21e-54: 191: 40.45		SFPQ_HUMAN (6-473): 2.47e-49: 181: 52.38
+	Hs
		1077418 CPSF7_HUMAN (1-525): 5.21e-54: 191: 40.45		ELAV1_HUMAN (70-207): 2.67e-45: 162: 27.82
+	Hs
		613386 SMCA2_HUMAN (63-551): 3.18e-44: 170: 15.19		SFPQ_HUMAN (6-473): 2.47e-49: 181: 52.38
+	Mm
		1150291 SMCA2_MOUSE (63-551): 9.15e-42: 163: 13.27		SFPQ_MOUSE (11-473): 3.28e-51: 186: 52.72
+	Mm
		1156792 CPSF6_MOUSE (1-520): 1.22e-73: 246: 100.00		RBM4_MOUSE (77-184): 5.61e-09: 59.7: 35.71
+	Hs
		1084591 CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62		RBM4B_HUMAN (77-184): 7.41e-09: 59.3: 35.71
+	Hs
		1084602 CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62		RBM4_HUMAN (77-184): 8.35e-09: 59.3: 35.71
+	Hs
		516495 PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75		PABP4_HUMAN (35-462): 4.6e-55: 196: 12.26
+	Hs
		1119141 PAP1L_HUMAN (77-320): 1.46e-35: 142: 15.69		PABP5_HUMAN (80-207): 9.91e-26: 110: 26.76
+	Hs
		516484 PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75		ELAV2_HUMAN (152-212): 9.98e-14: 74.5: 25.81
+	Hs
		516339 PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75		PABP1_HUMAN (140-386): 4.12e-13: 73.4: 14.18