HitPredict

Interactor 1: M9PHL4 (M9PHL4)
IST1 homolog (Charged multivesicular body protein 8)
Gene: Ist1

Interactor 2: Q9Y162 (Q9Y162)
BcDNA.GH02678 (Vacuolar protein sorting 4, isoform A (EC 3.6.1.3)) (Vacuolar protein sorting 4, isoform B)
Gene: Vps4

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	14605208, 22036573
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 384 Dm			1 442
+	Dm
		1373368 Q9VRY6_DROME (1-384): 3.87e-124: 366: 91.85		Q9Y162_DROME (1-442): 6.4e-129: 381: 100.00
+	Hs
		867078 IST1_HUMAN (1-383): 6.82e-109: 325: 46.13		VPS4A_HUMAN (7-441): 3.49e-126: 374: 73.79
+	Hs
		867072 IST1_HUMAN (1-383): 6.82e-109: 325: 46.13		SPAST_HUMAN (62-440): 1.51e-113: 348: 36.84
+	Ce
		105539 G5ECX8_CAEEL (2-384): 1.2e-101: 309: 38.06		Q9BL83_CAEEL (7-442): 3.16e-118: 353: 66.28
+	Ce
		106470 G5EDV6_CAEEL (2-384): 2.96e-98: 300: 38.01		Q9BL83_CAEEL (7-442): 3.16e-118: 353: 66.28
+	Dm
		116100 M9PHL4_DROME (1-384): 3.63e-137: 398: 100.00		SPAST_DROME (111-354): 2.56e-62: 216: 49.19
+	Dm
		1211024 Q9VRY6_DROME (1-384): 3.87e-124: 366: 91.85		SPAST_DROME (111-354): 2.56e-62: 216: 49.19
+	Sc
		857403 IST1_YEAST (6-226): 3.94e-62: 203: 25.32		VPS4_YEAST (1-442): 1.8e-112: 339: 57.66