HitPredict

Interactor 1: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Interactor 2: TBL1R (Q9BZK7)
F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)
Gene: TBL1XR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 974 Hs			1 514
+	Hs
		245613 WDR59_HUMAN (1-974): 0: 805: 100.00		TBL1X_HUMAN (1-514): 1.2e-150: 444: 86.34
+	Hs
		903313 WDR59_HUMAN (1-974): 0: 805: 100.00		WDR5_HUMAN (17-334): 1.51e-56: 193: 14.46
+	Hs
		245633 TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16		TBL1X_HUMAN (1-514): 1.2e-150: 444: 86.34
+	Hs
		792949 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		LIS1_HUMAN (4-430): 6.86e-96: 298: 17.26
+	Hs
		1083339 RBBP7_HUMAN (43-334): 3.53e-61: 216: 20.46		FBXW7_HUMAN (39-423): 4.25e-69: 236: 15.64
+	Hs
		903418 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		FBXW7_HUMAN (39-423): 4.25e-69: 236: 15.64
+	Hs
		903349 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		WDR5B_HUMAN (300-514): 6.92e-63: 210: 26.15
+	Hs
		1309163 TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16		TBL1Y_HUMAN (246-514): 5.05e-59: 205: 20.68
+	Hs
		903174 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		TBL3_HUMAN (131-514): 2.98e-55: 200: 15.00
+	Hs
		903077 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		WDR5_HUMAN (17-334): 1.51e-56: 193: 14.46
+	Sc
		630844 NLE1_YEAST (144-503): 1.94e-46: 176: 13.41		NLE1_YEAST (22-334): 5.73e-49: 178: 13.13
+	Hs
		196984 PRP4_HUMAN (2-175): 7.43e-33: 136: 12.85		WDR5_HUMAN (17-334): 1.51e-56: 193: 14.46
+	Hs
		903551 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		NLE1_HUMAN (23-293): 5.57e-36: 141: 13.61
+	Dm
		1358845 WDS_DROME (2-179): 1.14e-42: 161: 13.44		WDS_DROME (46-293): 5.44e-34: 133: 13.10
+	Hs
		282871 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		CIAO1_HUMAN (169-472): 3.95e-22: 99.4: 27.94
+	Hs
		1103007 FBXW7_HUMAN (219-506): 1.23e-21: 102: 12.93		SMU1_HUMAN (329-513): 4.3e-39: 150: 19.00
+	Hs
		903428 WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38		SNR40_HUMAN (50-195): 7.63e-12: 68.7: 11.92
+	Hs
		197071 PRP4_HUMAN (2-175): 7.43e-33: 136: 12.85		SNR40_HUMAN (50-195): 7.63e-12: 68.7: 11.92