HitPredict

Interactor 1: CUL1 (Q17389)
Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)
Gene: cul-1

Interactor 2: Q9U1Y9 (Q9U1Y9)
Skp1-related protein
Gene: skr-4

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11864566
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~Skp1_POZ
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Ce			1 159
+	Ce
		111133 CUL1_CAEEL (1-780): 0: 825: 100.00		SKR1_CAEEL (1-159): 1.43e-74: 222: 47.95
+	Mm
		1490137 CUL1_MOUSE (2-780): 0: 824: 45.71		SKP1_MOUSE (8-159): 2.17e-74: 221: 50.62
+	Hs
		992163 CUL1_HUMAN (2-780): 0: 824: 45.71		SKP1_HUMAN (8-159): 3.47e-74: 220: 50.62
+	Ce
		112389 CUL1_CAEEL (1-780): 0: 825: 100.00		G5EE67_CAEEL (1-159): 8.86e-66: 199: 80.12
+	Ce
		111665 CUL1_CAEEL (1-780): 0: 825: 100.00		G5EDD8_CAEEL (2-159): 4.29e-64: 195: 44.12
+	Hs
		992166 CUL4A_HUMAN (3-780): 0: 773: 26.50		SKP1_HUMAN (8-159): 3.47e-74: 220: 50.62
+	Ce
		113661 CUL1_CAEEL (1-780): 0: 825: 100.00		G5EG39_CAEEL (2-142): 5.48e-51: 163: 31.33
+	Ce
		111248 CUL1_CAEEL (1-780): 0: 825: 100.00		G5ECY4_CAEEL (2-142): 1.05e-50: 162: 32.00
+	Ce
		112167 CUL1_CAEEL (1-780): 0: 825: 100.00		G5EDY3_CAEEL (2-141): 5.19e-49: 158: 32.22
+	Ce
		113105 CUL1_CAEEL (1-780): 0: 825: 100.00		G5EFA9_CAEEL (2-142): 5.17e-48: 155: 31.33
+	Hs
		992167 CUL4B_HUMAN (3-780): 0: 758: 25.99		SKP1_HUMAN (8-159): 3.47e-74: 220: 50.62
+	Hs
		992165 CUL3_HUMAN (7-780): 0: 755: 25.77		SKP1_HUMAN (8-159): 3.47e-74: 220: 50.62
+	Dm
		305466 CUL1_DROME (3-780): 0: 747: 42.05		O77430_DROME (8-159): 3.96e-70: 210: 47.21
+	Dm
		1173416 CUL1_DROME (3-780): 0: 747: 42.05		Q7KJ69_DROME (8-159): 8.44e-67: 201: 45.63
+	Dm
		305471 Q5BI50_DROME (3-780): 0: 730: 26.85		O77430_DROME (8-159): 3.96e-70: 210: 47.21
+	At
		235699 CUL1_ARATH (8-780): 0: 713: 26.86		ASK11_ARATH (6-157): 8.45e-71: 211: 43.31
+	At
		1169264 CUL1_ARATH (8-780): 0: 713: 26.86		ASK15_ARATH (6-157): 2.43e-62: 191: 39.63
+	At
		306879 CUL1_ARATH (8-780): 0: 713: 26.86		ASK14_ARATH (6-157): 7.99e-63: 191: 38.61
+	At
		306844 CUL1_ARATH (8-780): 0: 713: 26.86		ASK16_ARATH (6-157): 2e-58: 181: 37.81
+	At
		306933 CUL1_ARATH (8-780): 0: 713: 26.86		ASK19_ARATH (6-156): 9.55e-58: 180: 34.41