HitPredict

Interactor 1: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Interactor 2: PACN2 (Q9UNF0)
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
Gene: PACSIN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0045296 - cadherin binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1025 Hs			1 486
+	Hs
		1167415 MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Hs
		1167441 MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		1052234 MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00		SRC8_HUMAN (47-484): 5.84e-38: 147: 11.40
+	Hs
		1355219 SWP70_HUMAN (370-824): 7.27e-58: 212: 19.22		PACN2_HUMAN (1-486): 1.94e-100: 311: 100.00
+	Hs
		1329256 TARA_HUMAN (231-985): 1.44e-51: 201: 35.57		PACN2_HUMAN (1-486): 1.94e-100: 311: 100.00
+	Hs
		1153451 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		PACN2_HUMAN (1-486): 1.94e-100: 311: 100.00
+	Hs
		1315994 TARA_HUMAN (231-985): 1.44e-51: 201: 35.57		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Hs
		1329254 TARA_HUMAN (231-985): 1.44e-51: 201: 35.57		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		1052264 DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61		SRC8_HUMAN (47-484): 5.84e-38: 147: 11.40
+	Hs
		1001582 PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51		FCHO2_HUMAN (14-444): 1.2e-45: 172: 14.06
+	Hs
		725061 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		148746 CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42		MYO1E_HUMAN (9-485): 6.43e-38: 149: 13.04
+	Hs
		724794 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		FCHO2_HUMAN (14-444): 1.2e-45: 172: 14.06
+	Hs
		724801 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		MYO1E_HUMAN (9-485): 6.43e-38: 149: 13.04
+	Hs
		724825 MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66		SRC8_HUMAN (47-484): 5.84e-38: 147: 11.40
+	Hs
		1052202 PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96		SRC8_HUMAN (47-484): 5.84e-38: 147: 11.40