HitPredict

Interactor 1: LMTK1 (Q6ZMQ8)
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
Gene: AATK

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1374 Hs			1 665
+	Hs
		557719 LMTK1_HUMAN (1-1374): 0: 976: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		1168427 LMTK1_HUMAN (1-1374): 0: 976: 100.00		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		1078847 LMTK1_HUMAN (1-1374): 0: 976: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		665643 EPHB2_HUMAN (6-404): 5.81e-122: 408: 22.77		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		1300028 LMTK3_HUMAN (7-1342): 9.67e-159: 518: 29.10		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		557670 ACK1_HUMAN (54-854): 2.25e-146: 474: 21.51		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924513 ACK1_HUMAN (54-854): 2.25e-146: 474: 21.51		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		209039 ACK1_HUMAN (54-854): 2.25e-146: 474: 21.51		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Mm
		337637 ABL1_MOUSE (113-878): 1.89e-124: 416: 19.42		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Mm
		222878 ACK1_MOUSE (55-976): 4.88e-124: 413: 20.25		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Hs
		557644 EPHB1_HUMAN (6-505): 2.12e-123: 410: 19.80		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		601492 FGFR2_HUMAN (17-456): 6.43e-126: 412: 19.75		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		872610 EPHB1_HUMAN (6-505): 2.12e-123: 410: 19.80		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		665574 EPHB2_HUMAN (6-404): 5.81e-122: 408: 22.77		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		872621 EPHB2_MOUSE (6-404): 9.08e-123: 408: 22.77		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		609244 FGFR3_HUMAN (29-448): 5.82e-123: 403: 23.42		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		601605 FGFR2_HUMAN (17-456): 6.43e-126: 412: 19.75		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		665608 EPHB2_HUMAN (6-404): 5.81e-122: 408: 22.77		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		222848 ACK1_MOUSE (55-976): 4.88e-124: 413: 20.25		SRBS1_MOUSE (3-155): 1.1e-13: 77: 34.15
+	Mm
		555266 FGFR1_MOUSE (28-460): 8.05e-121: 398: 21.00		NOSTN_MOUSE (240-335): 1.6e-09: 62.8: 39.58