HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30945288
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 759
+	Hs
		625417 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		515429 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		414909 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		515427 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		625416 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		960092 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		414908 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		515426 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55