HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	26186194, 27705803, 24981860, 33961781, 35933409, 22325352
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071339 - MLL1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 281 Hs			1 336
+	Mm
		222619 E2F6_MOUSE (1-272): 3.68e-95: 283: 87.13		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Mm
		1257625 Q8VHT4_MOUSE (37-272): 1.09e-86: 260: 88.14		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Hs
		1050532 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		265636 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		963597 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		265705 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		265610 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		265611 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Hs
		265660 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF3_HUMAN (36-334): 3.56e-44: 153: 18.15
+	Hs
		265707 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		265673 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF5_HUMAN (34-334): 1.89e-39: 141: 15.24
+	Hs
		1051778 E2F2_HUMAN (3-274): 1.57e-92: 282: 37.42		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		987969 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		135283 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		963679 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		749384 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		1071528 E2F5_HUMAN (61-273): 4.61e-72: 226: 34.51		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		1081395 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Hs
		749536 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		1050537 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76