HitPredict

Interactor 1: SGK1 (O00141)
Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)
Gene: SGK1

Interactor 2: PDPK1 (O15530)
3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
Gene: PDPK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.888

The method score is based on:

Property Details
Experiments 12387817, 10357815, 17916563, 17314099
Identification Methods pull down, enzymatic study, protein kinase assay
Interaction Type direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 4 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 431
Hs

1 556
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024