Protein: M3K4
Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)

Gene: M3K4, MAP3K4
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9Y6R4

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001890 - placenta development
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

912525

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

6

16

Small-scale

0.947

High

1054162

BTK
Tyrosine-protein kinase BTK

3

4

High-throughput

0.855

High

1201101

ACTBL
Beta-actin-like protein 2

3

9

High-throughput

0.855

High

853915

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

3

18

Small-scale

0.853

High

953221

ACTB
Actin, cytoplasmic 1

2

9

High-throughput

0.811

High

858740

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

18

Small-scale

0.806

High

853762

MK08
Mitogen-activated protein kinase 8

2

15

Small-scale

0.768

High

1491862

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

14

Small-scale

0.757

High

275471

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

4

2

Small-scale

0.707

High

1491387

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

3

High-throughput

0.692

High

977869

ACTA
Actin, aortic smooth muscle

1

10

High-throughput

0.691

High

993409

ACTG
Actin, cytoplasmic 2

1

9

High-throughput

0.691

High

1384319

SH3K1
SH3 domain-containing kinase-binding protein 1

3

7

Small-scale

0.675

High

665300

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

3

2

Small-scale

0.672

High

508930

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

Small-scale

0.665

High

162069

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

16

Small-scale

0.647

High

177975

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.647

High

891931

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.647

High

955811

CDC42
Cell division control protein 42 homolog

1

2

Small-scale

0.647

High

988872

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

Small-scale

0.647

High

1038387

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

18

Small-scale

0.647

High

332195

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

2

2

Small-scale

0.644

High

273604

DJC13
DnaJ homolog subfamily C member 13

1

8

High-throughput

0.618

High

1101721

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.618

High

158046

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.618

High

181202

AXIN1
Axin-1

1

8

Small-scale

0.618

High

214477

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

8

Small-scale

0.618

High

831741

CCNF
Cyclin-F

1

3

High-throughput

0.618

High

857011

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.618

High

1120420

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

High-throughput

0.618

High

1125308

FAK2
Protein-tyrosine kinase 2-beta

1

4

Small-scale

0.618

High

1158632

CDC37
Hsp90 co-chaperone Cdc37

1

6

Small-scale

0.618

High

1256326

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.618

High

1295609

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

Small-scale

0.618

High

1434382

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.618

High

1462026

ALK
ALK tyrosine kinase receptor

1

7

Small-scale

0.618

High

993059

RACK1
Small ribosomal subunit protein RACK1

2

11

Small-scale

0.584

High

1414814

TRAF4
TNF receptor-associated factor 4

2

7

Small-scale

0.584

High

638566

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.575

High

886158

CXCR3
C-X-C chemokine receptor type 3

1

3

High-throughput

0.575

High

1391893

AURKB
Aurora kinase B

1

15

High-throughput

0.575

High

1459855

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.575

High

250917

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.553

High

959434

RAP1B
Ras-related protein Rap-1b

1

3

High-throughput

0.553

High

552896

TPR
Nucleoprotein TPR

1

6

High-throughput

0.541

High

990934

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.541

High

1280948

CNTRL
Centriolin

1

4

High-throughput

0.541

High

349720

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

1

High-throughput

0.536

High

407743

S100B
Protein S100-B

1

2

High-throughput

0.536

High

1402750

TCPQM
T-complex protein 1 subunit theta-like 2

1

6

High-throughput

0.536

High

262349

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.514

High

1293944

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

2

High-throughput

0.514

High

278183

FLNB
Filamin-B

1

7

Small-scale

0.500

High

983100

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.493

High

223459

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

348020

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

348820

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

Small-scale

0.479

High

456902

ANXA2
Annexin A2

1

2

Small-scale

0.479

High

688350

TTP
mRNA decay activator protein ZFP36

1

2

Small-scale

0.479

High

1036035

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

1178662

KIF7
Kinesin-like protein KIF7

1

3

High-throughput

0.479

High

1278707

KI21A
Kinesin-like protein KIF21A

1

4

High-throughput

0.479

High

1311744

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

8

High-throughput

0.479

High

1340698

NEDD1
Protein NEDD1

1

3

High-throughput

0.479

High

1405080

SORT
Sortilin

1

1

High-throughput

0.479

High

1459512

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1121106

BOP1
Ribosome biogenesis protein BOP1

1

3

High-throughput

0.470

High

62224

DEN11
DENN domain-containing protein 11

1

0

High-throughput

0.458

High

1093095

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.458

High

1329970

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1448413

PICK1
PRKCA-binding protein

1

6

High-throughput

0.457

High

730405

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

469243

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.437

High

648395

USF1
Upstream stimulatory factor 1

1

2

High-throughput

0.437

High

959103

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.437

High

1100600

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.437

High

1142052

EEA1
Early endosome antigen 1

1

5

High-throughput

0.437

High

1322820

CNTRB
Centrobin

1

8

High-throughput

0.437

High

1389534

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

11

High-throughput

0.437

High

1403186

INT14
Integrator complex subunit 14

1

1

High-throughput

0.437

High

1462476

AP4E1
AP-4 complex subunit epsilon-1

1

3

High-throughput

0.437

High

1491223

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.437

High

1251704

T184A
Transmembrane protein 184A

1

0

High-throughput

0.426

High

1461798

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

50744

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.407

High

1258634

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

8

High-throughput

0.407

High

711213

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.338

High

1330767

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

1219203

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1338461

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1396429

PHAR3
Phosphatase and actin regulator 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025