Protein: DCLK1
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)

Gene: DCLK1
Organism: Homo sapiens
Interactions: 127
UniProt ID: O15075

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176785

DCX
Neuronal migration protein doublecortin

4

6

High-throughput

0.903

High

176799

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.691

High

176800

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

7

High-throughput

0.691

High

176820

ACK1
Activated CDC42 kinase 1

1

18

High-throughput

0.691

High

176829

DDB1
DNA damage-binding protein 1

1

3

High-throughput

0.691

High

176875

FEM1A
Protein fem-1 homolog A

1

4

High-throughput

0.691

High

176897

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.691

High

176830

DGUOK
Deoxyguanosine kinase, mitochondrial

3

3

High-throughput

0.667

High

176883

KTU
Protein kintoun

3

3

High-throughput

0.667

High

176862

FEM1C
Protein fem-1 homolog C

1

4

High-throughput

0.618

High

176786

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.618

High

176787

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

14

High-throughput

0.618

High

176796

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.618

High

176801

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.618

High

176802

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.618

High

176809

AFAD
Afadin

1

20

High-throughput

0.618

High

176818

CDK16
Cyclin-dependent kinase 16

1

7

High-throughput

0.618

High

176822

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

13

High-throughput

0.618

High

176824

MELK
Maternal embryonic leucine zipper kinase

1

14

High-throughput

0.618

High

176825

ZN638
Zinc finger protein 638

1

4

High-throughput

0.618

High

176835

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

8

High-throughput

0.618

High

176842

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

176846

PHLB2
Pleckstrin homology-like domain family B member 2

1

9

High-throughput

0.618

High

176848

KSR1
Kinase suppressor of Ras 1

1

12

High-throughput

0.618

High

176868

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.618

High

176877

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.618

High

176879

TRI36
E3 ubiquitin-protein ligase TRIM36

1

19

High-throughput

0.618

High

176880

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.618

High

176896

PPM1H
Protein phosphatase 1H

1

13

High-throughput

0.618

High

176900

GAB2
GRB2-associated-binding protein 2

1

10

High-throughput

0.618

High

124146

HAX1
HCLS1-associated protein X-1

3

3

High-throughput

0.609

High

176832

BOREA
Borealin

3

1

High-throughput

0.609

High

176889

NUFP1
FMR1-interacting protein NUFIP1

3

2

High-throughput

0.609

High

176886

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.586

High

176823

DCTN1
Dynactin subunit 1

2

10

High-throughput

0.584

High

176783

DCLK1
Serine/threonine-protein kinase DCLK1

1

17

Small-scale

0.575

High

176793

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

176833

EFHC2
EF-hand domain-containing family member C2

2

16

High-throughput

0.553

High

176892

CDC23
Cell division cycle protein 23 homolog

2

6

High-throughput

0.553

High

176834

CE170
Centrosomal protein of 170 kDa

1

5

High-throughput

0.553

High

176838

AN34A
Ankyrin repeat domain-containing protein 34A

1

7

High-throughput

0.553

High

176839

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.553

High

176858

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.553

High

176878

PKHA5
Pleckstrin homology domain-containing family A member 5

1

16

High-throughput

0.553

High

176894

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.553

High

176898

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

13

High-throughput

0.553

High

176795

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.536

High

176798

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

176803

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

176804

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.536

High

176806

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.536

High

176807

GPM6A
Neuronal membrane glycoprotein M6-a

1

3

High-throughput

0.536

High

176811

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

176812

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

15

High-throughput

0.536

High

176814

1433E
14-3-3 protein epsilon

1

12

High-throughput

0.536

High

176815

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

176819

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

176826

TRIP6
Thyroid receptor-interacting protein 6

1

4

High-throughput

0.536

High

176856

FBLI1
Filamin-binding LIM protein 1

1

4

High-throughput

0.536

High

176861

DCAF5
DDB1- and CUL4-associated factor 5

1

7

High-throughput

0.536

High

176869

NEB2
Neurabin-2

1

20

High-throughput

0.536

High

176895

NEB1
Neurabin-1

1

20

High-throughput

0.536

High

176792

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.533

High

176876

RTKN
Rhotekin

1

0

High-throughput

0.517

High

176817

LRP2
Low-density lipoprotein receptor-related protein 2

1

0

High-throughput

0.513

High

176794

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

176816

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.489

High

176871

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.489

High

176784

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

176789

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

7

High-throughput

0.479

High

176797

NF1
Neurofibromin

1

17

High-throughput

0.479

High

176805

SYUA
Alpha-synuclein

1

5

Small-scale

0.479

High

176810

HDAC4
Histone deacetylase 4

1

13

High-throughput

0.479

High

176813

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

176827

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

6

High-throughput

0.479

High

176836

SPD2A
SH3 and PX domain-containing protein 2A

1

6

High-throughput

0.479

High

176837

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

176840

LARP1
La-related protein 1

1

1

High-throughput

0.479

High

176850

RPTOR
Regulatory-associated protein of mTOR

1

6

High-throughput

0.479

High

176851

NAV1
Neuron navigator 1

1

2

High-throughput

0.479

High

176855

HDAC7
Histone deacetylase 7

1

13

High-throughput

0.479

High

176857

DEP1B
DEP domain-containing protein 1B

1

7

High-throughput

0.479

High

176859

ARHG2
Rho guanine nucleotide exchange factor 2

1

13

Small-scale

0.479

High

176866

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

16

High-throughput

0.479

High

176872

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

2

High-throughput

0.479

High

176882

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

1

High-throughput

0.479

High

176887

CING
Cingulin

1

3

High-throughput

0.479

High

176888

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

176890

XPO7
Exportin-7

1

5

High-throughput

0.479

High

176893

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.479

High

176899

MARE3
Microtubule-associated protein RP/EB family member 3

1

3

High-throughput

0.479

High

176905

KCTD3
BTB/POZ domain-containing protein KCTD3

1

9

High-throughput

0.479

High

176863

KLH15
Kelch-like protein 15

1

8

Small-scale

0.470

High

176788

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

176791

NADK
NAD kinase

1

0

High-throughput

0.458

High

176849

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

176885

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

176808

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

176870

CK5P2
CDK5 regulatory subunit-associated protein 2

1

9

High-throughput

0.445

High

176902

ITM2B
Integral membrane protein 2B

1

11

High-throughput

0.445

High

104856

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

176790

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.437

High

176821

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

7

High-throughput

0.437

High

176828

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.437

High

176831

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

176841

GGYF2
GRB10-interacting GYF protein 2

1

8

High-throughput

0.437

High

176843

CE128
Centrosomal protein of 128 kDa

1

6

High-throughput

0.437

High

176844

SYDE1
Rho GTPase-activating protein SYDE1

1

10

High-throughput

0.437

High

176845

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.437

High

176847

LCA5
Lebercilin

1

4

High-throughput

0.437

High

176852

F110B
Protein FAM110B

1

3

High-throughput

0.437

High

176853

DEN1A
DENN domain-containing protein 1A

1

4

High-throughput

0.437

High

176854

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

7

High-throughput

0.437

High

176867

CIC
Protein capicua homolog

1

8

High-throughput

0.437

High

176873

F110A
Protein FAM110A

1

3

High-throughput

0.437

High

176891

NGAP
Ras GTPase-activating protein nGAP

1

17

High-throughput

0.437

High

176903

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.437

High

176904

STA13
StAR-related lipid transfer protein 13

1

6

High-throughput

0.437

High

176864

CEP63
Centrosomal protein of 63 kDa

1

5

High-throughput

0.407

High

171047

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.282

High

176901

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.279

Low

176860

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

176865

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

176874

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

176884

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

176881

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025