HitPredict

Interactor 1: RAPH1 (Q70E73)
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)
Gene: RAPH1

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	25517094, 24076656
Identification Methods	pull down, protein array, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1250 Hs			1 347
+	Hs
		1173966 RAPH1_HUMAN (1-1250): 0: 627: 100.00		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		1173965 RAPH1_HUMAN (1-1250): 0: 627: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Mm
		94694 F2Z3U3_MOUSE (1-1250): 0: 583: 89.65		SH3G3_MOUSE (1-346): 1.4e-88: 271: 86.71
+	Hs
		1191264 AB1IP_HUMAN (152-749): 2.63e-146: 459: 40.43		PACN2_HUMAN (1-343): 3.2e-38: 143: 16.45
+	Hs
		1191260 AB1IP_HUMAN (152-749): 2.63e-146: 459: 40.43		PACN1_HUMAN (6-342): 5.44e-34: 131: 14.90
+	Hs
		924543 GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Ce
		666202 MIG10_CAEEL (190-655): 8.61e-87: 301: 32.21		SEM5_CAEEL (272-339): 1.24e-21: 93.6: 43.66
+	Dm
		993213 Q9VWB7_DROME (252-913): 6.42e-71: 261: 23.05		GRAP_DROME (272-339): 1.72e-20: 90.2: 40.85
+	Mm
		88460 D3Z656_MOUSE (503-893): 4.52e-10: 66.4: 12.59		SH3G3_MOUSE (1-346): 1.4e-88: 271: 86.71
+	Mm
		88459 D3Z656_MOUSE (503-893): 4.52e-10: 66.4: 12.59		SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63
+	Mm
		761854 ZO1_MOUSE (514-1213): 1.47e-26: 120: 12.73		SRC8_MOUSE (7-343): 2.48e-52: 183: 13.24
+	Hs
		1264828 TITIN_HUMAN (586-1241): 1.11e-11: 71.9: 13.92		SHLB1_HUMAN (10-342): 1.46e-66: 215: 24.22
+	Ce
		70017 G5EBN5_CAEEL (739-1246): 1.77e-10: 67.9: 10.24		SH3GH_CAEEL (1-345): 1.27e-65: 213: 42.93
+	Hs
		596232 TITIN_HUMAN (586-1241): 1.11e-11: 71.9: 13.92		NEBU_HUMAN (7-342): 2.57e-37: 144: 16.06
+	Hs
		554292 MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		924760 PRG4_HUMAN (510-1162): 1.96e-15: 84.1: 12.08		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38