Protein: CHD1L
Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1)

Gene: CHD1L
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q86WJ1

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0003678 - DNA helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

591719

H2AX
Histone H2AX

3

20

Small-scale

0.871

High

1127731

HLTF
Helicase-like transcription factor

2

18

High-throughput

0.811

High

1163030

H2B2E
Histone H2B type 2-E

2

20

Small-scale

0.789

High

1016994

H33
Histone H3.3

2

20

Small-scale

0.767

High

487490

PARP1
Poly [ADP-ribose] polymerase 1

8

20

Small-scale

0.753

High

1292490

APLF
Aprataxin and PNK-like factor

6

0

Small-scale

0.697

High

558246

XRCC6
X-ray repair cross-complementing protein 6

4

10

Small-scale

0.694

High

256914

H2B1K
Histone H2B type 1-K

1

20

Small-scale

0.691

High

502043

H2AZ
Histone H2A.Z

1

20

Small-scale

0.691

High

502413

H2A1
Histone H2A type 1

1

20

High-throughput

0.691

High

754899

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.691

High

1232689

H2A2A
Histone H2A type 2-A

1

20

Small-scale

0.691

High

1272802

H2A3
Histone H2A type 3

1

20

Small-scale

0.691

High

1292517

RN146
E3 ubiquitin-protein ligase RNF146

5

0

Small-scale

0.679

High

1292520

PARP2
Poly [ADP-ribose] polymerase 2

3

13

Small-scale

0.675

High

1292524

SP16H
FACT complex subunit SPT16

3

6

Small-scale

0.675

High

302881

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

17

High-throughput

0.675

High

617712

XRCC1
DNA repair protein XRCC1

4

0

Small-scale

0.667

High

332419

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

2

High-throughput

0.662

High

589074

RFA2
Replication protein A 32 kDa subunit

3

6

Small-scale

0.656

High

537455

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.628

High

1032831

XPC
DNA repair protein complementing XP-C cells

2

2

High-throughput

0.628

High

1292512

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

2

High-throughput

0.628

High

853328

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.618

High

953927

IF4A1
Eukaryotic initiation factor 4A-I

1

11

Small-scale

0.618

High

979924

H4
Histone H4

1

14

High-throughput

0.618

High

980895

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

998497

H31
Histone H3.1

1

20

High-throughput

0.618

High

1014148

CBX1
Chromobox protein homolog 1

1

20

Small-scale

0.618

High

1097398

CBX3
Chromobox protein homolog 3

1

20

Small-scale

0.618

High

1292498

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.618

High

1292522

FBW1A
F-box/WD repeat-containing protein 1A

1

14

High-throughput

0.618

High

559409

XRCC5
X-ray repair cross-complementing protein 5

2

10

Small-scale

0.611

High

768572

RFA3
Replication protein A 14 kDa subunit

2

5

Small-scale

0.611

High

675072

TNR6
Tumor necrosis factor receptor superfamily member 6

3

2

High-throughput

0.609

High

1292499

RN166
E3 ubiquitin-protein ligase RNF166

3

3

High-throughput

0.609

High

1292494

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

1008220

PRKDC
DNA-dependent protein kinase catalytic subunit

2

10

Small-scale

0.601

High

1209343

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.601

High

1292521

TRI33
E3 ubiquitin-protein ligase TRIM33

2

18

Small-scale

0.595

High

260141

BRD4
Bromodomain-containing protein 4

2

20

Small-scale

0.584

High

695861

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

8

Small-scale

0.584

High

1254480

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

920087

PLK1
Serine/threonine-protein kinase PLK1

1

11

High-throughput

0.536

High

1065280

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1091310

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.536

High

1111083

SNW1
SNW domain-containing protein 1

1

6

High-throughput

0.536

High

1150242

TEAD2
Transcriptional enhancer factor TEF-4

1

5

High-throughput

0.536

High

1292500

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1292507

CDC5L
Cell division cycle 5-like protein

1

12

High-throughput

0.536

High

1292509

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

1292513

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.536

High

754058

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.514

High

832318

ID1
DNA-binding protein inhibitor ID-1

1

0

High-throughput

0.513

High

1204370

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1292502

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

886529

CTCF
Transcriptional repressor CTCF

1

6

Small-scale

0.508

High

1006518

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.501

High

137754

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.489

High

1286605

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

1

High-throughput

0.489

High

1292492

RETR2
Reticulophagy regulator 2

1

1

High-throughput

0.489

High

652537

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

High-throughput

0.481

High

1292504

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.481

High

218406

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

242177

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

293955

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

372466

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

401084

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.479

High

412201

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

578511

BRAF
Serine/threonine-protein kinase B-raf

1

12

High-throughput

0.479

High

629943

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

728321

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

High-throughput

0.479

High

769879

RFC2
Replication factor C subunit 2

1

3

Small-scale

0.479

High

791023

TALDO
Transaldolase

1

1

High-throughput

0.479

High

831008

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

879241

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

19

High-throughput

0.479

High

1024675

VIGLN
Vigilin

1

19

High-throughput

0.479

High

1146244

ZMY11
Zinc finger MYND domain-containing protein 11

1

20

Small-scale

0.479

High

1156674

NF2L2
Nuclear factor erythroid 2-related factor 2

1

15

Small-scale

0.479

High

1276436

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

1289793

SHLD2
Shieldin complex subunit 2

1

1

High-throughput

0.479

High

1292497

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1292501

CHFR
E3 ubiquitin-protein ligase CHFR

1

12

Small-scale

0.479

High

1292503

ZN764
Zinc finger protein 764

1

2

Small-scale

0.479

High

1292505

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1292508

EPAS1
Endothelial PAS domain-containing protein 1

1

7

Small-scale

0.479

High

1292510

API5
Apoptosis inhibitor 5

1

3

Small-scale

0.479

High

1292515

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1292516

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

14

Small-scale

0.479

High

1292518

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

2

High-throughput

0.479

High

1292495

BAALC
Brain and acute leukemia cytoplasmic protein

1

0

Small-scale

0.460

High

64771

RIMC1
RAB7A-interacting MON1-CCZ1 complex subunit 1

1

0

High-throughput

0.458

High

639384

5NTD
5'-nucleotidase

1

0

High-throughput

0.458

High

1292511

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.457

High

892589

DNLI3
DNA ligase 3

1

2

High-throughput

0.445

High

1292491

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

1

High-throughput

0.445

High

1292506

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1292525

NFS1
Cysteine desulfurase

1

2

High-throughput

0.445

High

1178230

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

1292514

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

1292519

KLK11
Kallikrein-11

1

4

High-throughput

0.437

High

1292523

KLK5
Kallikrein-5

1

4

High-throughput

0.437

High

1129246

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.426

High

437722

HEPS
Serine protease hepsin

1

2

High-throughput

0.407

High

142223

CCL22
C-C motif chemokine 22

2

0

High-throughput

0.328

High

562183

LAMP2
Lysosome-associated membrane glycoprotein 2

2

0

High-throughput

0.328

High

1254118

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

1108509

NAR3
Ecto-ADP-ribosyltransferase 3

2

0

High-throughput

0.318

High

1101568

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

0

High-throughput

0.313

High

251369

GMDS
GDP-mannose 4,6 dehydratase

1

0

High-throughput

0.279

Low

688585

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

0

High-throughput

0.279

Low

760463

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

1292493

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

850897

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

1

0

High-throughput

0.249

Low

1239233

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1292496

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025