HitPredict

Interactor 1: HECW1 (Q76N89)
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Gene: HECW1

Interactor 2: UB2J2 (Q8N2K1)
Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2)
Gene: UBE2J2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	26949039
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1606 Hs			1 259
+	Hs
		849351 HECW1_HUMAN (1-1606): 0: 1184: 100.00		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		919762 HECW1_HUMAN (1-1606): 0: 1184: 100.00		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		895825 HECW1_HUMAN (1-1606): 0: 1184: 100.00		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		919889 HECW2_HUMAN (22-1606): 0: 955: 55.12		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		895935 HECW2_HUMAN (22-1606): 0: 955: 55.12		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		1231676 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2J2_HUMAN (1-259): 1.21e-110: 320: 100.00
+	Hs
		1294888 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2D4_HUMAN (12-156): 2.24e-67: 207: 24.16
+	Hs
		849411 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		919827 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		895882 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		1282329 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2E3_HUMAN (1-157): 8.61e-62: 194: 25.47
+	Hs
		1294835 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2E2_HUMAN (1-157): 3.56e-61: 193: 25.47
+	Hs
		851871 ITCH_HUMAN (865-1606): 0: 695: 30.78		UB2E1_HUMAN (1-157): 7.51e-61: 192: 24.85
+	Hs
		808052 NEDD4_HUMAN (307-1604): 0: 656: 21.43		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		808078 NEDD4_HUMAN (307-1604): 0: 656: 21.43		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		808069 NEDD4_HUMAN (307-1604): 0: 656: 21.43		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15
+	Hs
		849451 SMUF2_HUMAN (1017-1606): 0: 646: 35.34		UB2D1_HUMAN (12-156): 3.85e-66: 204: 24.16
+	Hs
		919867 SMUF2_HUMAN (1017-1606): 0: 646: 35.34		UB2D2_HUMAN (12-156): 3.65e-66: 204: 22.82
+	Hs
		808057 NEDD4_HUMAN (307-1604): 0: 656: 21.43		UB2E1_HUMAN (1-157): 7.51e-61: 192: 24.85
+	Hs
		895918 SMUF2_HUMAN (1017-1606): 0: 646: 35.34		UB2D3_HUMAN (12-156): 2.8e-65: 201: 22.15