Protein: FKBP
FK506-binding protein 1 (FKBP) (12-kDa cytosolic FK506-binding protein) (FKBP-12) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (EC 5.2.1.8) (Rapamycin-binding protein)

Gene: FKBP, FPR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: P20081

Gene Ontology (top 5):
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005527 - macrolide binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

628050

TOR2
Serine/threonine-protein kinase TOR2

4

8

Small-scale

0.900

High

392208

HSP82
ATP-dependent molecular chaperone HSP82

4

20

High-throughput

0.878

High

628058

TOR1
Serine/threonine-protein kinase TOR1

2

8

Small-scale

0.838

High

578822

HSC82
ATP-dependent molecular chaperone HSC82

2

20

High-throughput

0.767

High

533506

AK
Aspartokinase

6

1

Small-scale

0.738

High

628085

FAP1
FKBP12-associated protein 1

5

2

Small-scale

0.711

High

599321

FUS3
Mitogen-activated protein kinase FUS3

1

6

High-throughput

0.647

High

628086

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

10

High-throughput

0.647

High

628039

KCC2
Calcium/calmodulin-dependent protein kinase II

1

3

High-throughput

0.618

High

628098

ASR1
Alcohol-sensitive RING finger protein 1

2

0

High-throughput

0.598

High

628042

CDC48
Cell division control protein 48

2

9

High-throughput

0.594

High

628045

HS104
Heat shock protein 104

2

3

High-throughput

0.594

High

394224

EF1A
Elongation factor 1-alpha

2

1

High-throughput

0.584

High

628061

GBLP
Small ribosomal subunit protein RACK1

2

7

Small-scale

0.584

High

628076

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

628065

SPP41
Protein SPP41

2

5

Small-scale

0.576

High

628071

YIQ1
Uncharacterized protein YIL161W

2

0

High-throughput

0.576

High

628051

TFB1
General transcription and DNA repair factor IIH subunit TFB1

2

0

High-throughput

0.563

High

628092

SSL1
General transcription and DNA repair factor IIH subunit SSL1

2

0

High-throughput

0.563

High

628075

BUD27
Bud site selection protein 27

1

0

Small-scale

0.558

High

525892

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.552

High

361418

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

368221

TRP
Tryptophan synthase

1

1

High-throughput

0.536

High

416080

SYTC
Threonine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.536

High

581821

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.536

High

598948

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.536

High

628049

FIMB
Fimbrin

1

4

High-throughput

0.536

High

628062

SSZ1
Ribosome-associated complex subunit SSZ1

1

8

High-throughput

0.536

High

628063

KOG1
Target of rapamycin complex 1 subunit KOG1

1

4

Small-scale

0.536

High

628072

MLP2
Protein MLP2

1

5

High-throughput

0.536

High

628073

SYA
Alanine--tRNA ligase, mitochondrial

1

9

High-throughput

0.536

High

628102

HSH49
Protein HSH49

1

2

High-throughput

0.536

High

628037

ACE2
Metallothionein expression activator

1

1

High-throughput

0.515

High

452560

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.513

High

628043

PYRD
Dihydroorotate dehydrogenase

1

0

High-throughput

0.513

High

628094

YM94
Uncharacterized protein YMR315W

1

0

High-throughput

0.513

High

628095

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

628099

CUE5
Ubiquitin-binding protein CUE5

1

0

Small-scale

0.513

High

628090

HMO1
High mobility group protein 1

1

5

Small-scale

0.506

High

366767

IPYR
Inorganic pyrophosphatase

1

4

High-throughput

0.500

High

366922

ATPB
ATP synthase subunit beta, mitochondrial

1

8

High-throughput

0.500

High

367690

ENO1
Enolase 1

1

4

High-throughput

0.500

High

416367

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

416517

HXKB
Hexokinase-2

1

1

High-throughput

0.500

High

460310

SYV
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.500

High

481476

HSP73
Heat shock protein SSA3

1

15

High-throughput

0.500

High

554879

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.500

High

592000

VATB
V-type proton ATPase subunit B

1

8

High-throughput

0.500

High

598806

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.500

High

610088

PDI
Protein disulfide-isomerase

1

16

High-throughput

0.500

High

622316

ACON
Aconitate hydratase, mitochondrial

1

4

High-throughput

0.500

High

628038

HSP74
Heat shock protein SSA4

1

15

High-throughput

0.500

High

628040

TKT1
Transketolase 1

1

6

High-throughput

0.500

High

628068

SAHH
Adenosylhomocysteinase

1

3

High-throughput

0.500

High

628077

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

3

High-throughput

0.500

High

628078

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.500

High

531535

RT02
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.493

High

628052

NGR1
Negative growth regulatory protein NGR1

1

0

High-throughput

0.493

High

628057

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

0

High-throughput

0.493

High

628069

GDI1
Rab GDP-dissociation inhibitor

1

4

High-throughput

0.489

High

628074

LST8
Target of rapamycin complex subunit LST8

1

5

Small-scale

0.489

High

628041

CG22
G2/mitotic-specific cyclin-2

1

0

High-throughput

0.486

High

628088

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.486

High

432288

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

439238

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

555003

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

626576

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

434812

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

594174

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

628044

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

628047

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

628055

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.479

High

628079

MOG1
Nuclear import protein MOG1

1

3

High-throughput

0.479

High

628080

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

628084

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

628087

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

628089

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

628096

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

628097

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

628101

H2AZ
Histone H2A.Z

1

7

Small-scale

0.479

High

628054

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

628059

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

628064

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

628067

ECM1
Shuttling pre-60S factor ECM1

1

0

Small-scale

0.458

High

628083

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

538320

PYC1
Pyruvate carboxylase 1

1

1

High-throughput

0.457

High

628046

EF2
Elongation factor 2

1

2

High-throughput

0.457

High

510180

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

523022

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

543778

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

628048

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

628070

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

628056

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

628066

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

628100

RS10A
Small ribosomal subunit protein eS10A

1

7

High-throughput

0.437

High

628081

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

628093

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

628091

YMX7
Probable ADP-ribose 1''-phosphate phosphatase YML087W

1

0

High-throughput

0.265

Low

405024

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

628060

MID2
Cell wall integrity sensor MID2

1

0

Small-scale

0.251

Low

628082

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.251

Low

628053

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025