HitPredict

Interactor 1: SNP23 (O00161)
Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)
Gene: SNAP23

Interactor 2: STX1A (Q16623)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.743

Property	Details
Experiments	9168999, 12828989, 12651853, 8663154, 9852078, 24722188, 26359495
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0006887 - exocytosis GO:0031201 - SNARE complex GO:0031629 - synaptic vesicle fusion to presynaptic active zone membrane and 1 others more... GO:0043005 - neuron projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 288
+	Hs
		118010 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX1B_HUMAN (1-288): 5.2e-85: 258: 83.33
+	Mm
		140165 SNP23_MOUSE (1-211): 2.55e-68: 209: 87.20		STX1A_MOUSE (1-288): 3.69e-86: 261: 98.26
+	Rn
		250768 SNP23_RAT (1-211): 6.18e-69: 211: 87.20		STX1B_RAT (1-288): 5.2e-85: 258: 83.33
+	Hs
		117977 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX2_HUMAN (1-288): 6.6e-82: 250: 63.89
+	Dm
		1098103 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		STX1A_DROME (2-287): 2.6e-75: 233: 69.90
+	Hs
		118028 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX3_HUMAN (1-288): 2.81e-64: 205: 62.41
+	Hs
		118025 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX4_HUMAN (1-287): 1.22e-63: 203: 43.58
+	Ce
		183449 O62414_CAEEL (4-209): 2.49e-58: 184: 46.60		STX1A_CAEEL (2-283): 8.04e-75: 232: 64.31
+	Rn
		250771 SNP23_RAT (1-211): 6.18e-69: 211: 87.20		STX3_RAT (1-288): 2.84e-63: 202: 61.38
+	Mm
		140169 SNP23_MOUSE (1-211): 2.55e-68: 209: 87.20		STX3_MOUSE (1-264): 1.06e-62: 201: 64.29
+	Rn
		250772 SNP23_RAT (1-211): 6.18e-69: 211: 87.20		STX4_RAT (1-287): 7.68e-61: 196: 43.24
+	Hs
		117936 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX11_HUMAN (1-274): 2.87e-54: 179: 29.72
+	Hs
		66335 A8K287_HUMAN (1-211): 1.06e-71: 218: 100.00		STX11_HUMAN (1-274): 2.87e-54: 179: 29.72
+	Hs
		118048 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX12_HUMAN (26-271): 2.32e-51: 171: 24.50
+	Hs
		118053 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX19_HUMAN (1-264): 1.03e-50: 170: 30.55
+	Hs
		117929 SNP23_HUMAN (1-211): 1.06e-71: 218: 100.00		STX7_HUMAN (37-286): 6.99e-50: 167: 25.30
+	At
		1351792 SNP33_ARATH (1-210): 2.42e-60: 192: 22.54		SY121_ARATH (19-266): 2.64e-58: 191: 22.27
+	Dm
		1098004 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		STX5_DROME (2-268): 2.15e-51: 176: 16.61
+	At
		1114737 SNP33_ARATH (1-210): 2.42e-60: 192: 22.54		SY111_ARATH (2-266): 6.77e-51: 171: 22.88
+	Dm
		1182812 Q9VH76_DROME (6-211): 4.47e-61: 191: 47.57		STX4_DROME (27-267): 6.23e-51: 172: 24.48