Protein: M3K6
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)

Gene: M3K6, MAP3K6
Organism: Homo sapiens
Interactions: 52
UniProt ID: O95382

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0006468 - protein phosphorylation
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

312810

M3K5
Mitogen-activated protein kinase kinase kinase 5

5

19

Small-scale

0.924

High

312805

PKHO2
Pleckstrin homology domain-containing family O member 2

3

4

High-throughput

0.770

High

312785

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

20

High-throughput

0.737

High

312795

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

10

High-throughput

0.726

High

312798

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.712

High

312799

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

312800

HS904
Putative heat shock protein HSP 90-alpha A4

2

20

High-throughput

0.712

High

212338

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

10

High-throughput

0.691

High

312779

MK04
Mitogen-activated protein kinase 4

1

20

High-throughput

0.691

High

312787

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

19

High-throughput

0.691

High

312788

ACTB
Actin, cytoplasmic 1

1

14

High-throughput

0.691

High

312791

ACTA
Actin, aortic smooth muscle

1

14

High-throughput

0.691

High

312811

UBAC1
Ubiquitin-associated domain-containing protein 1

2

0

High-throughput

0.679

High

312818

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

2

High-throughput

0.667

High

312789

1433G
14-3-3 protein gamma

3

20

Small-scale

0.662

High

312781

1433S
14-3-3 protein sigma

3

20

Small-scale

0.656

High

312793

1433F
14-3-3 protein eta

3

20

Small-scale

0.650

High

312771

RASH
GTPase HRas

1

17

Small-scale

0.647

High

71060

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

5

High-throughput

0.618

High

312796

CDC37
Hsp90 co-chaperone Cdc37

1

16

High-throughput

0.618

High

312772

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

312773

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

312790

1433E
14-3-3 protein epsilon

2

20

Small-scale

0.584

High

312794

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

7

High-throughput

0.574

High

312801

RN123
E3 ubiquitin-protein ligase RNF123

2

5

High-throughput

0.574

High

312813

LIMD1
LIM domain-containing protein 1

2

2

High-throughput

0.574

High

312815

PCDA4
Protocadherin alpha-4

2

1

High-throughput

0.574

High

312774

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.536

High

312776

S100P
Protein S100-P

1

20

High-throughput

0.536

High

312775

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.489

High

312778

SPB3
Serpin B3

1

2

High-throughput

0.489

High

312784

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.489

High

312786

PEX5
Peroxisomal targeting signal 1 receptor

1

9

High-throughput

0.489

High

312803

ASPM
Abnormal spindle-like microcephaly-associated protein

1

20

High-throughput

0.489

High

312804

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

312808

EFMT3
EEF1A lysine methyltransferase 3

1

8

High-throughput

0.489

High

312812

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.489

High

312816

PCDAC
Protocadherin alpha-12

1

1

High-throughput

0.489

High

312817

LIMC1
LIM and calponin homology domains-containing protein 1

1

16

High-throughput

0.489

High

312777

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

312780

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.479

High

312792

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

312819

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

2

High-throughput

0.479

High

312797

CL16A
Protein CLEC16A

1

3

High-throughput

0.437

High

312807

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.437

High

312814

FBW1B
F-box/WD repeat-containing protein 11

1

20

Small-scale

0.437

High

312770

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

312782

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.279

Low

312783

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.279

Low

312802

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

312806

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

312809

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024